Heparin-appended polycaprolactone core/corona nanoparticles for site specific delivery of 5-fluorouracil

被引：7
|
作者：
Garg, Ashish [1 ]
Patel, Vaibhav [1 ]
Sharma, Rajeev [2 ]
Jain, Amit [3 ]
Yadav, Awesh K. [3 ]
机构：
[1] Guru Ramdas Khalsa Inst Sci & Technol, Drug Delivery & Nanotechnol Labs, Dept Pharmaceut, Pharm, Jabalpur, India
[2] Dr HS Gour Vishwavidyalaya, Dept Pharmaceut Sci, Drug Delivery Res Lab, Sagar, Madhya Pradesh, India
[3] Bhagyoday Tirth Pharm Coll, Dept Pharmaceut, Nanotechnol Project Labs, Sagar, Madhya Pradesh, India
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 06期
关键词：
Cellular cytotoxicity; 5-fluorouracil; heparin; nanoparticles; polycaprolactone; CHOLESTEROL-RICH NANOEMULSION; DRUG-DELIVERY; SIZE DISTRIBUTION; CELLS; LDE;
D O I：
10.1080/21691401.2016.1203793
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The aim of the present work is to formulate heparin-modified-polycaprolactone (HEP) core shell nanoparticles (NPs) of 5-fluorouracil (5-FU). These NPs were characterized for various in vitro parameters like particle size, zeta potential, etc. HEP NPs were found to maintain comparatively slower drug release pattern (98.9% in 96h) than PCL NPs. Cytotoxicity studies demonstrated a massive cytotoxic potential of 5-FU-loaded HEP NPs in A549, MDA-MD-435, and SK-OV-3 cancer cell lines. Pharmacokinetic parameters were also determined in blood after IV administration of HEP NPs: AUC, C-max, MRT, and T-max values are 6096.075 +/- 5.90gh/mL, 144.38 +/- 1.52g/L, 58.71 +/- 0.25h, 96 +/- 0.50h, respectively and 117.92 +/- 1.78, 45.35 +/- 3.00, 1.2 +/- 0.25, 0.5 +/- 0.02 in plain 5-FU solution.
引用
收藏
页码：1146 / 1155
页数：10
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