Synthesis of some fluorinated acids, ketones and alcohols derived from 3,3,3-trifluoropropionic acid

被引：13

作者：

Xiao, L ^{[1
]}

Kitazume, T ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Bioengn, Midori Ku, Yokohama, Kanagawa 226, Japan

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1997年 / 86卷 / 01期

关键词：

enzymatic hydrolysis; 3-fluoro-2-alkenoic acids; 2,2,2-trifluoroethyl alkyl ketones;

D O I：

10.1016/S0022-1139(97)00068-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The stereoselective synthesis of 3-fluoro-2-alkenoic acids was achieved by the reaction of lithium 3,3,3-trifluoropropionate with Grignard reagents. 2,2,2-Trifluoroethyl alkyl ketones were prepared by the reaction of 3,3,3-trifluoropropionic acid chloride with either lithium dialkylcuprates or magnesium dialkylcuprates. Optically active 1,1,1-uifluoro-3-alkanols were obtained by the enzymatic hydrolysis of the corresponding acetates. (C) 1997 Elsevier Science S.A.

引用

页码：99 / 104

页数：6