The significance of thymidine phosphorylase expression in colorectal cancer

被引：1

作者：

Katsumata, K

Sumi, T

Yamashita, S

Takahashi, S

Mori, M

Baba, T

Murohashi, T

Nagashima, K

Ashizawa, T

Yamamoto, K

Koyanagi, Y

Katoh, K

机构：

[1] Tokyo Med Univ, Dept Surg 3, Tokyo, Japan

[2] Tokyo Med Univ, Hachioji Med Ctr, Dept Gastroenterol, Tokyo, Japan

来源：

ONCOLOGY REPORTS | 2001年 / 8卷 / 01期

关键词：

colorectal cancer; thymidine phosphorylase; enzyme activity; immunostaining; malignancy;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We measured thymidine phosphorylase activity in colorectal cancer tissue and conducted immunostaining to investigate enzyme expression in the tumor tissue. The results showed a correlation between staining ratio of thymidine phosphorylase and cancer progression as well as a correlation between enzyme activity and staining ratios of cancer cells and stromal cells. Since enzyme activity levels can be judged by staining ratios, this method may be useful for assessing cancer malignancy.

引用

页码：127 / 130

页数：4

共 17 条

[1]

AKITA Y, 1998, J HEPATOL, V29, P290

[2] Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancer [J].

Blum, JL ;

Jones, SE ;

Buzdar, AU ;

LoRusso, PM ;

Kuter, I ;

Vogel, C ;

Osterwalder, B ;

Burger, HU ;

Brown, CS ;

Griffin, T .

JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (02) :485-493

[3] FLUORINATED PYRIMIDINE NUCLEOSIDES .3. SYNTHESIS AND ANTI-TUMOR ACTIVITY OF A SERIES OF 5'-DEOXY-5-FLUOROPYRIMIDINE NUCLEOSIDES [J].

COOK, AF ;

HOLMAN, MJ ;

KRAMER, MJ ;

TROWN, PW .

JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (11) :1330-1335

[4] CYTOKINES INDUCE THYMIDINE PHOSPHORYLASE EXPRESSION IN TUMOR-CELLS AND MAKE THEM MORE SUSCEPTIBLE TO 5'-DEOXY-5-FLUOROURIDINE [J].

EDA, H ;

FUJIMOTO, K ;

WATANABE, S ;

URA, M ;

HINO, A ;

TANAKA, Y ;

WADA, K ;

ISHITSUKA, H .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1993, 32 (05) :333-338

[5] ANGIOGENIC FACTOR [J].

FURUKAWA, T ;

YOSHIMURA, A ;

SUMIZAWA, T ;

HARAGUCHI, M ;

AKIYAMA, S ;

FUKUI, K ;

ISHIZAWA, M ;

YAMADA, Y .

NATURE, 1992, 356 (6371) :668-668

[6]

HEMELIN R, 1994, GASTROENTEROLOGY, V106, P42

[7]

KONO A, 1983, CHEM PHARM BULL, V31, P175

[8] Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma [J].

Maeda, K ;

Chung, YS ;

Ogawa, Y ;

Takatsuka, S ;

Kang, SM ;

Ogawa, M ;

Sawada, T ;

Onoda, N ;

Kato, Y ;

Sowa, M .

BRITISH JOURNAL OF CANCER, 1996, 73 (08) :884-888

[9]

MONDEN T, 1998, J JPN SURG SOC, V99, P446

[10]

Nishida M, 1996, BIOL PHARM BULL, V19, P1407

← 1 2 →