Lymph Node Cellular Dynamics in Cancer and HIV: What Can We Learn for the Follicular CD4 (Tfh) Cells?

被引：9
作者：
Poultsidi, Antigoni [1 ]
Dimopoulos, Yiannis [2 ]
He, Ting-Fang [3 ]
Chavakis, Triantafyllos [4 ]
Saloustros, Emmanouil [5 ]
Lee, Peter P. [3 ]
Petrovas, Constantinos [2 ]
机构：
[1] Univ Thessaly, Med Sch, Dept Surg, Larisa, Greece
[2] NIAID, Tissue Anal Core, Immunol Lab, Vaccine Res Ctr,NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
[3] City Hope Comprehens Canc Ctr, Beckman Res Inst, Dept Immunooncol, Duarte, CA USA
[4] Tech Univ Dresden, Inst Clin Chem & Lab Med, Dresden, Germany
[5] Univ Thessaly, Med Sch, Dept Internal Med, Larisa, Greece
来源：
FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷
基金：
美国国家卫生研究院;
关键词：
cancer; HIV; Tfh cells; lymph nodes; follicles; IMMUNODEFICIENCY VIRUS-INFECTION; REGULATORY T-CELLS; MYELOID DENDRITIC CELLS; NEGATIVE BREAST-CANCER; FIBROBLASTIC RETICULAR CELLS; GERMINAL CENTER RESPONSE; HELPER-CELLS; B-CELLS; SIV INFECTION; RHESUS MACAQUES;
D O I：
10.3389/fimmu.2018.02233
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Lymph nodes (LNs) are central in the generation of adaptive immune responses. Follicular helper CD4 T (Tfh) cells, a highly differentiated CD4 population, provide critical help for the development of antigen-specific B cell responses within the germinal center. Throughout the past decade, numerous studies have revealed the important role of Tfh cells in Human Immunodeficiency Virus (HIV) pathogenesis as well as in the development of neutralizing antibodies post-infection and post-vaccination. It has also been established that tumors influence various immune cell subsets not only in their proximity, but also in draining lymph nodes. The role of local or tumor associated lymph node Tfh cells in disease progression is emerging. Comparative studies of Tfh cells in chronic infections and cancer could therefore provide novel information with regards to their differentiation plasticity and to the mechanisms regulating their development.
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页数：12
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