Gold-catalyzed efficient synthesis of azepan-4-ones via a two-step [5+2] annulation

被引：50

作者：

Cui, Li ^{[1
]}

Ye, Longwu ^{[1
]}

Zhang, Liming ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 19期

关键词：

PONNDORF-VERLEY REDUCTION; ASYMMETRIC REDUCTION; RING-CLOSURE; AU CATALYSIS; MIGRATION; ANALOGS; ALLENES; OLEFINS; KETONES; ALKYNES;

D O I：

10.1039/c001314e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A surprisingly efficient synthesis of azepan-4-ones via a two-step [5 + 2] annulation is developed. This reaction involves a key gold catalysis and shows generally high regioselectivities and good to excellent diastereoselectivities.

引用

页码：3351 / 3353

页数：3

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