Consensus-based semi-quantitative ultrasound scoring system for gout lesions: Results of an OMERACT Delphi process and web-reliability exercise

被引：35

作者：

Christiansen, Sara Nysom ^{[1
,2
]}

Filippou, Georgios ^{[3
,4
]}

Scire, Carlo Alberto ^{[3
]}

Balint, Peter, V ^{[5
]}

Bruyn, George A. W. ^{[6
]}

Dalbeth, Nicola ^{[7
]}

Dejaco, Christian ^{[8
,9
]}

Delle Sedie, Andrea ^{[10
]}

Filippucci, Emilio ^{[11
]}

Hammer, Hilde B. ^{[12
,13
]}

Iagnocco, Annamaria ^{[14
]}

Keen, Helen, I ^{[15
]}

Kissin, Eugene Y. ^{[16
]}

Koski, Juhani ^{[17
]}

Mandl, Peter ^{[18
]}

Martin, Julia ^{[7
]}

De Miguel, Eugenio ^{[19
]}

Moller, Ingrid ^{[20
]}

Naredo, Esperanza ^{[21
,22
]}

Pineda, Carlos ^{[23
]}

Schmidt, Wolfgang A. ^{[24
]}

Stewart, Sarah ^{[7
]}

D'Agostino, Maria Antonietta ^{[25
,26
]}

Terslev, Lene ^{[1
,2
]}

机构：

[1] Rigshosp, Copenhagen Ctr Arthrit Res, Ctr Rheumatol & Spine Dis, Glostrup, Denmark

[2] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[3] Univ Ferrara, Rheumatol Sect, Dept Med Sci, Ferrara, Italy

[4] Luigi Sacco Univ Hosp Milan, Rheumatol Unit, Milan, Italy

[5] Natl Inst Rheumatism & Physiotherapy, Rheumatol Dept 3, Budapest, Hungary

[6] MC Grp, Dept Rheumatol, Lelystad, Netherlands

[7] Univ Auckland, Bone & Joint Res Grp, Fac Med, Auckland, New Zealand

[8] Med Univ Graz, Dept Rheumatol, Graz, Austria

[9] Hosp Brunico SABES ASDAA, Dept Rheumatol, Brunico, Italy

[10] Univ Pisa, Rheumatol Unit, Pisa, Italy

[11] Univ Politecn Marche, Dept Rheumatol, Clin Reumatol, Ancona, Italy

[12] Diakonhjemmet Hosp, Dept Rheumatol, Oslo, Norway

[13] Univ Oslo, Oslo, Norway

[14] Univ Torino, Acad Rheumatol Ctr, DSCB, Turin, Italy

[15] Univ Western Australia, Sch Med & Pharmacol, Fiona Stanley Hosp Unit, Perth, WA, Australia

[16] Boston Univ, Div Rheumatol, Boston, MA 02215 USA

[17] Mikkeli Cent Hosp, Dept Internal Med, Mikkeli, Finland

[18] Med Univ Vienna, Div Rheumatol, Vienna, Austria

[19] Hosp Univ La Paz, Dept Rheumatol, Madrid, Spain

[20] Univ Barcelona, Inst Poal Reumatol, Barcelona, Spain

[21] IIS Fdn Jimenez Diaz, Hosp Univ Fdn Jimenez Diaz, Dept Rheumatol, Joint & Bone Res Unit, Madrid, Spain

[22] Univ Autonoma Madrid, Madrid, Spain

[23] Inst Nacl Rehabil, Div Musculoskeletal & Rheumat Dis, Mexico City, DF, Mexico

[24] Immanuel Krankenhaus Berlin, Dept Rheumatol, Med Ctr Rheumatol, Berlin Buch, Berlin, Germany

[25] Ambroise Pare Hosp, Dept Rheumatol, Boulogne, France

[26] Versailles St Quentin En Yvelines Univ, Boulogne, France

来源：

SEMINARS IN ARTHRITIS AND RHEUMATISM | 2021年 / 51卷 / 03期

关键词：

Ultrasound; Gout; OMERACT; Scoring system; Delphi exercise; Reliability; Outcome measure; AMERICAN-COLLEGE; OUTCOME MEASURE; MANAGEMENT; DISEASE; AGREEMENT; BURDEN; RISK; UK;

D O I：

10.1016/j.semarthrit.2020.11.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: This study aimed to develop (1) a new ultrasound definition for aggregates and (2) a semi-quantitative ultrasound scoring system (0-3) for tophus, double contour and aggregates. Furthermore, the intraand inter-reader reliabilities of both the re-defined aggregates and the semi-quantitative scoring system were assessed using static image exercises. Methods: Thirty-seven rheumatologists were invited. A Delphi process was used for re-defining aggregates and for selecting a semi-quantitative scoring system with >75% agreement obligate for reaching consensus. Subsequently, a web-based exercise on static ultrasound images was conducted in order to assess the reliability of both the re-defined aggregates and the semi-quantitative scoring system. Results: Twenty rheumatologists contributed to all rounds of the Delphi and image exercises. A consensual re-definition of aggregates was obtained after three Delphi rounds but needed an overarching principle for scoring aggregates in patients. A consensus-based semi-quantitative ultrasound scoring system for gout lesions was developed after two Delphi rounds. The re-definition of aggregates showed good intra- and inter-reader reliability (k-values 0.71 and 0.61). The reliabilities of the scoring system were good for all lesions with slightly higher intra-reader (k-values 0.74-0.80) than inter-reader reliabilities (k-values 0.61-0.67). Conclusion: A re-definition of aggregates was obtained with a good reliability when assessing static images. The first consensus-based semi-quantitative ultrasound scoring system for gout-specific lesions was devel-oped with good inter-and intra-reader reliability for all lesions when tested in static images. The next step is to assess the reliabilities when scoring lesions in patients. (c) 2021 Elsevier Inc. All rights reserved.

引用

页码：644 / 649

页数：6

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