Pleiotrophin inhibits melanogenesis via Erk1/2-MITF signaling in normal human melanocytes

被引：24

作者：

Choi, Woo Jong ^{[1
,2
]}

Kim, Misun ^{[1
]}

Park, Ji-Youn ^{[1
]}

Park, Tae Jun ^{[2
]}

Kang, Hee Young ^{[1
]}

机构：

[1] Ajou Univ, Sch Med, Dept Dermatol, Suwon 441749, South Korea

[2] Ajou Univ, Sch Med, Dept Biochem & Mol Biol, Suwon 441749, South Korea

来源：

PIGMENT CELL & MELANOMA RESEARCH | 2015年 / 28卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

melanocytes; melanogenesis; pleiotrophin; MITF; Erk1; 2; MIDKINE; SKIN; MICROPHTHALMIA; PIGMENTATION; EXPRESSION; KINASE;

D O I：

10.1111/pcmr.12309

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pleiotrophin (PTN) is a secreted heparin-binding protein that is involved in various biological functions of cell growth and differentiation. Little is known about the effects of PTN on the melanocyte function and skin pigmentation. In this study, we investigated whether PTN would affect melanogenesis. PTN was expressed in melanocytes and fibroblasts of human skin. Transfection studies revealed that PTN decreased melanogenesis, probably through MITF degradation via Erk1/2 activation in melanocytes. The inhibitory action of PTN in pigmentation was further confirmed in ex vivo cultured skin and in the melanocytes cocultured with fibroblasts. These findings suggest that PTN is a crucial factor for the regulation of melanogenesis in the skin.

引用

页码：51 / 60

页数：11

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