A 24-weeks real-world experience of dupilumab in adolescents with moderate-to-severe atopic dermatitis

被引：30

作者：

Napolitano, Maddalena ^{[1
]}

Fabbrocini, Gabriella ^{[2
]}

Potestio, Luca ^{[2
]}

Fontanella, Giuseppina ^{[2
]}

Picone, Vincenzo ^{[2
]}

Bennardo, Luigi ^{[3
]}

Scalvenzi, Massimiliano ^{[2
]}

Patruno, Cataldo ^{[3
]}

机构：

[1] Univ Molise, Dept Med & Hlth Sci Vincenzo Tiberio, Campobasso, Italy

[2] Univ Naples Federico II, Sect Dermatol, Dept Clin Med & Surg, Naples, Italy

[3] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy

来源：

DERMATOLOGIC THERAPY | 2022年 / 35卷 / 08期

关键词：

adolescents; dupilumab; efficacy; real world; safety; ECZEMA;

D O I：

10.1111/dth.15588

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Dupilumab is a monoclonal antibody approved for the treatment of moderate-to-severe atopic dermatitis (AD) in patients aged >= 12 years. Large, double-blind, randomized, placebo-controlled trials showed its efficacy and safety in adolescents. However, real-life data are few. The aim of this monocentric retrospective observational study (December 2020-November 2021) was to assess the effectiveness and safety of dupilumab in AD adolescents treated for at least 24 weeks. For each patient demographic features, clinical data and adverse events (AEs) were collected. Eczema Area and Severity Index (EASI), Numerical Rating Scale (NRS) for pruritus (P-NRS) and for sleep disturbances (S-NRS), and Children Dermatology Life Quality Index (cDLQI) were assessed at baseline, week (W)4, W16, and W24. Twenty-seven patients (18 males; 15.23 +/- 3.54 years) were enrolled. Dupilumab was administered subcutaneously at dosage of 600 mg induction dose, followed by 300 mg every 2 weeks in 14 (51.85%) patients with a weight >= 60 kg, while 13 (48.15%) patients with a weight <60 kg were treated with dupilumab 200 mg every 2 weeks after a loading dose of 400 mg. The mean EASI score at baseline was 26.96 +/- 4.93 and significantly reduced to 3.74 +/- 3.47 at W16 (<0.001), and to 3.4 +/- 5.04 at W24 (p < 0.001). P-NRS (9.14 +/- 0.94 at baseline vs. 2.33 +/- 4.93 at W16 [p < 0.001], and 1.45 +/- 2.35 at W24 [p < 0.001]), S-NRS (7.88 +/- 1.64 at baseline vs. 0.92 +/- 1.35 at W16 [p < 0.001], and 1.66 +/- 2.84 at W24 [p < 0.0001]) and cDLQI (26.62 +/- 4.45 vs. 2.18 +/- 3.51 at baseline vs. 2.18 +/- 3.51 at W16 [p < 0.001], and 3.4 +/- 5.02 at W24 [p < 0.001]) showed a statistically significative improvement as well. Injection-site reaction (5/27; 18.52%), conjunctivitis (2/27; 7.41%), and asthenia (2/27; 7.41%) were the main AEs collected. This study seems to confirm the efficacy and safety of dupilumab in adolescents with moderate-to-severe AD also in real-life setting.

引用

页数：5

共 19 条

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