Synthesis and crystal structure of ethyl 7-chloro-3-amino-9-(4-bromophenyl)thieno-[3,2-b]benzothiazine 4,4-dioxide 2-carboxylate

被引：0
作者：
Charris, Jaime
Barazarte, Arthur
Ferrer, Rosa
Camacho, Jos
Gamboa, Neira
Rodrigues, Juan
Atencio, Reinaldo
Gonzalez, Teresa
机构：
[1] Cent Univ Venezuela, Fac Farm, Lab Sintesis Organ, Caracas 1041A, Venezuela
[2] Cent Univ Venezuela, Fac Farm, Lab Bioquim, Caracas 1041A, Venezuela
[3] Inst Venezolano Invest Cient, Lab Sintesis & Caracterizac Nuevos Mat, Caracas 1020A, Venezuela
来源：
JOURNAL OF CHEMICAL RESEARCH-S | 2007年 / 01期
关键词：
benzothiazine; crystal structure; antimalarial;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The X-ray crystal structure of 7-chloro-3-amino-9-(4-bromophenyl)thieno-[3,2-b]benzothiazine 4,4-dioxide 2-carboxylate 1 is determined. The thiophene ring and the exocyclic ester group adopt a co-planar conformation, which is stabilised by an intramolecular hydrogen bond. The moderate antimalarial activity shown by this compound appears to be related to the formation of such an intramolecular N-H center dot center dot center dot O =C hydrogen bond.
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页码：16 / 18
页数：3
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