Synthesis and crystal structure of ethyl 7-chloro-3-amino-9-(4-bromophenyl)thieno-[3,2-b]benzothiazine 4,4-dioxide 2-carboxylate

被引：0

作者：

Charris, Jaime

Barazarte, Arthur

Ferrer, Rosa

Camacho, Jos

Gamboa, Neira

Rodrigues, Juan

Atencio, Reinaldo

Gonzalez, Teresa

机构：

[1] Cent Univ Venezuela, Fac Farm, Lab Sintesis Organ, Caracas 1041A, Venezuela

[2] Cent Univ Venezuela, Fac Farm, Lab Bioquim, Caracas 1041A, Venezuela

[3] Inst Venezolano Invest Cient, Lab Sintesis & Caracterizac Nuevos Mat, Caracas 1020A, Venezuela

来源：

JOURNAL OF CHEMICAL RESEARCH-S | 2007年 / 01期

关键词：

benzothiazine; crystal structure; antimalarial;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The X-ray crystal structure of 7-chloro-3-amino-9-(4-bromophenyl)thieno-[3,2-b]benzothiazine 4,4-dioxide 2-carboxylate 1 is determined. The thiophene ring and the exocyclic ester group adopt a co-planar conformation, which is stabilised by an intramolecular hydrogen bond. The moderate antimalarial activity shown by this compound appears to be related to the formation of such an intramolecular N-H center dot center dot center dot O =C hydrogen bond.

引用

页码：16 / 18

页数：3

共 14 条

[1]

Allen F.H., 1993, CHEM AUTOMAT NEWS, V8, P31

[2]

*BRUK AN XRAY SYST, 1998, CRYST SOFTW PACK SHE

[3]

CAPARELLI MV, 2006, IN PRESS J CHEM CRYS

[4]

Charris J, 2005, J CHEM RES, P27

[5] Synthesis and antimalarial activity of E-2-quinolinylbenzocycloalkanones [J].

Charris, JE ;

Domínguez, JN ;

Gamboa, N ;

Rodrigues, JR ;

Angel, JE .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (09) :875-881

[6] 1H and 13C NMR spectral characterization of some antimalarial in vitro 2,4-diamino-10-methylpyrimido[4,5-b]-5-quinolone derivatives [J].

Charris, JE ;

Domínguez, JN ;

Gamboa, N ;

Angel, J ;

Piña, N ;

Guerra, M ;

Michelena, E ;

López, SE .

MAGNETIC RESONANCE IN CHEMISTRY, 2002, 40 (07) :477-479

[7]

CHARRIS JE, 2005, HETEROCYCL COMMUN, V11, P2005

[8] Stage-specific activity of potential antimalarial compounds measured in vitro by flow cytometry in comparison to optical microscopy and hypoxanthine uptake [J].

Contreras, CE ;

Rivas, MA ;

Domínguez, J ;

Charris, J ;

Palacios, M ;

Bianco, NE ;

Blanca, I .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2004, 99 (02) :179-184

[9] Synthesis of quinolinyl chalcones and evaluation of their antimalarial activity [J].

Domínguez, JN ;

Charris, JE ;

Lobo, G ;

de Domínguez, NG ;

Moreno, MM ;

Riggione, F ;

Sanchez, E ;

Olson, J ;

Rosenthal, PJ .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2001, 36 (06) :555-560

[10]

Domínguez JN, 2002, ARZNEIMITTEL-FORSCH, V52, P482

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