Design and synthesis of β-methoxyacrylate analogues via click chemistry and biological evaluations

被引:33
作者
Chen, Hao [1 ]
Taylor, Janet L. [1 ]
Abrams, Suzanne R. [1 ]
机构
[1] Natl Res Council Canada, Inst Plant Biotechnol, Saskatoon, SK S7N 0W9, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
antifungal; strobulirin natural products; beta-methoxylacrylates; click chemistry;
D O I
10.1016/j.bmcl.2007.01.021
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A library of potential antifungal triazole-modified P-methoxyacrylate analogues was designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction or 'click chemistry'. Subsequent biological screening revealed that some compounds displayed low to moderate antifungal activity toward pathogenic fungi and low phytotoxicity. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1979 / 1983
页数:5
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