A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity

被引：19

作者：

Zheng, Xin-Heng ^{[1
]}

Huang, Yuan-Peng ^{[1
]}

Liang, Qiu-Ping ^{[1
]}

Xu, Wei ^{[1
]}

Lan, Ting ^{[1
]}

Zhou, Guang-Xiong ^{[1
]}

机构：

[1] Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

来源：

MOLECULES | 2018年 / 23卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Lycium yunnanense Kuang; lyciumamide K; ECD calculations; antioxidant activities; oxygen radical absorbance capacity (ORAC) assay; BARK; CHINENSE; GLYCOSIDES; BARBARUM; AMIDES; FRUITS; ASSAY;

D O I：

10.3390/molecules23040770

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new lignanamide (1), lyciumamide K, together with four known analogues (2-5), was isolated from the root of Lycium yunnanense Kuang. Based on HR-ESI-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was confirmed, including its absolute configuration. Evaluation of the antioxidant activity of compounds 1-5 in the oxygen radical absorption capacity (ORAC) assay showed that they all exhibited significant antioxidant activities. Particularly, compound 1 showed the best activity with ORAC values (U/mol) of 7.90 +/- 0.52. Thus, the new lignanamide may be a good source of bioavtive and protective compounds.

引用

页数：8

共 27 条

[1] Bioactive Octahydroxylated C21 Steroids from the Root Bark of Lycium chinense [J].