Altered Hyaluronan Biosynthesis and Cancer Progression: an Immunological Perspective

被引：20
作者：
Alaniz, Laura [1 ,2 ]
Garcia, Mariana [1 ,2 ]
Rizzo, Miguel [1 ]
Piccioni, Flavia [1 ]
Mazzolini, Guillermo [1 ,2 ]
机构：
[1] Austral Univ, Gene Therapy Lab, Sch Med, Buenos Aires, DF, Argentina
[2] Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 13期
关键词：
Extracellular matrix; hyaluronan; CD44; immune system; dendritic cells; cancer; CELL-SURFACE CD44; MAMMARY-CARCINOMA CELLS; DENDRITIC CELLS; T-CELLS; SIGNALING PATHWAYS; TUMOR PROGRESSION; IMMUNE-RESPONSE; BREAST-CANCER; EXPRESSION; OLIGOSACCHARIDES;
D O I：
10.2174/138955709790361485
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hyaluronan is a glycosaminglycan present in practically all tissues as an important component of the extracellular matrix. In spite of its apparent simple chemical structure, hyaluronan is a molecule with multiple and complex physiogical and pathological functions. Hyaluronan is able to regulate a variety of biological processes such as cellular growth, migration, differentiation and inflammation, not only in normal but also in cancer tissues. Besides, increasing evidence suggests hyaluronan as a potent modulator of immune responses which supports a potential role of this molecule in cancer immunotherapy.
引用
收藏
页码：1538 / 1546
页数：9
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