Altered Hyaluronan Biosynthesis and Cancer Progression: an Immunological Perspective

被引：20
作者：
Alaniz, Laura [1 ,2 ]
Garcia, Mariana [1 ,2 ]
Rizzo, Miguel [1 ]
Piccioni, Flavia [1 ]
Mazzolini, Guillermo [1 ,2 ]
机构：
[1] Austral Univ, Gene Therapy Lab, Sch Med, Buenos Aires, DF, Argentina
[2] Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 13期
关键词：
Extracellular matrix; hyaluronan; CD44; immune system; dendritic cells; cancer; CELL-SURFACE CD44; MAMMARY-CARCINOMA CELLS; DENDRITIC CELLS; T-CELLS; SIGNALING PATHWAYS; TUMOR PROGRESSION; IMMUNE-RESPONSE; BREAST-CANCER; EXPRESSION; OLIGOSACCHARIDES;
D O I：
10.2174/138955709790361485
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hyaluronan is a glycosaminglycan present in practically all tissues as an important component of the extracellular matrix. In spite of its apparent simple chemical structure, hyaluronan is a molecule with multiple and complex physiogical and pathological functions. Hyaluronan is able to regulate a variety of biological processes such as cellular growth, migration, differentiation and inflammation, not only in normal but also in cancer tissues. Besides, increasing evidence suggests hyaluronan as a potent modulator of immune responses which supports a potential role of this molecule in cancer immunotherapy.
引用
收藏
页码：1538 / 1546
页数：9
相关论文
共 86 条
  • [31] Altered hyaluronan biosynthesis in cancer progression
    Itano, Naoki
    Kimata, Koji
    [J]. SEMINARS IN CANCER BIOLOGY, 2008, 18 (04) : 268 - 274
  • [32] Biology of the lymphatic marker LYVE-1 and applications in research into lymphatic trafficking and lymphangiogenesis
    Jackson, DG
    [J]. APMIS, 2004, 112 (7-8) : 526 - 538
  • [33] Hyaluronan in tissue injury and repair
    Jiang, Dianhua
    Liang, Jiurong
    Noble, Paul W.
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2007, 23 : 435 - 461
  • [34] Enhanced cell surface CD44 variant (v6, v9) expression by osteopontin in breast cancer epithelial cells facilitates tumor cell migration: Novel post-transcriptional, post-translational regulation
    Khan, Subarna A.
    Cook, Amy C.
    Kappil, Maya
    Gunthert, Ursula
    Chambers, Ann F.
    Tuck, Alan B.
    Denhardt, David T.
    [J]. CLINICAL & EXPERIMENTAL METASTASIS, 2005, 22 (08) : 663 - 673
  • [35] CD44-mediated uptake and degradation of hyaluronan
    Knudson, W
    Chow, G
    Knudson, CB
    [J]. MATRIX BIOLOGY, 2002, 21 (01) : 15 - 23
  • [36] HYALURONIC-ACID BONDED TO CELL-CULTURE SURFACES INHIBITS THE PROGRAM OF MYOGENESIS
    KUJAWA, MJ
    PECHAK, DG
    FISZMAN, MY
    CAPLAN, AI
    [J]. DEVELOPMENTAL BIOLOGY, 1986, 113 (01) : 10 - 16
  • [37] The microenvironments of multistage carcinogenesis
    Laconi, Ezio
    Doratiotto, Silvia
    Vineis, Paolo
    [J]. SEMINARS IN CANCER BIOLOGY, 2008, 18 (05) : 322 - 329
  • [38] Laurent Torvard C., 1996, Immunology and Cell Biology, V74, pA1, DOI 10.1038/icb.1996.32
  • [39] Lesley J, 2000, J BIOL CHEM, V275, P26967
  • [40] Hyaluronan in limb morphogenesis
    Li, Yingcui
    Toole, Bryan P.
    Dealy, Caroline N.
    Kosher, Robert A.
    [J]. DEVELOPMENTAL BIOLOGY, 2007, 305 (02) : 411 - 420
123456789