Altered Hyaluronan Biosynthesis and Cancer Progression: an Immunological Perspective

被引：20

作者：

Alaniz, Laura ^{[1
,2
]}

Garcia, Mariana ^{[1
,2
]}

Rizzo, Miguel ^{[1
]}

Piccioni, Flavia ^{[1
]}

Mazzolini, Guillermo ^{[1
,2
]}

机构：

[1] Austral Univ, Gene Therapy Lab, Sch Med, Buenos Aires, DF, Argentina

[2] Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 13期

关键词：

Extracellular matrix; hyaluronan; CD44; immune system; dendritic cells; cancer; CELL-SURFACE CD44; MAMMARY-CARCINOMA CELLS; DENDRITIC CELLS; T-CELLS; SIGNALING PATHWAYS; TUMOR PROGRESSION; IMMUNE-RESPONSE; BREAST-CANCER; EXPRESSION; OLIGOSACCHARIDES;

D O I：

10.2174/138955709790361485

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hyaluronan is a glycosaminglycan present in practically all tissues as an important component of the extracellular matrix. In spite of its apparent simple chemical structure, hyaluronan is a molecule with multiple and complex physiogical and pathological functions. Hyaluronan is able to regulate a variety of biological processes such as cellular growth, migration, differentiation and inflammation, not only in normal but also in cancer tissues. Besides, increasing evidence suggests hyaluronan as a potent modulator of immune responses which supports a potential role of this molecule in cancer immunotherapy.

引用

页码：1538 / 1546

页数：9

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