Biomaterial stiffness determines stem cell fate

被引：60

作者：

Lv, Hongwei ^{[1
]}

Wang, Heping ^{[2
]}

Zhang, Zhijun ^{[3
]}

Yang, Wang ^{[3
]}

Liu, Wenbin ^{[3
]}

Li, Yulin ^{[1
]}

Li, Lisha ^{[1
]}

机构：

[1] Jilin Univ, Norman Bethune Med Coll, Minist Educ, Key Lab Pathobiol, Changchun 130021, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Sch, Tongji Hosp, Dept Neurosurg, Wuhan, Peoples R China

[3] Jilin Univ, Coll Clin Med, Changchun, Peoples R China

来源：

LIFE SCIENCES | 2017年 / 178卷

基金：

中国国家自然科学基金;

关键词：

Stiffness; Stem cells; Differentiation; SUBSTRATE STIFFNESS; OSTEOGENIC DIFFERENTIATION; MECHANICAL-PROPERTIES; MATRIX; HYDROGELS; MODULATION; ELASTICITY; MODULUS; SCAFFOLD; ADHESION;

D O I：

10.1016/j.lfs.2017.04.014

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Stem cells have potential to develop into numerous cell types, thus they are good cell source for tissue engineering. As an external physical signal, material stiffness is capable of regulating stem cell fate. Biomaterial stiffness is an important parameter in tissue engineering. We summarize main measurements of material stiffness under different condition, then list and compare three main methods of controlling stiffness (material amount, crosslinldng density and photopolymeriztion time) which interplay with one another and correlate with stiffness positively, and current advances in effects of biomaterial stiffness on stem cell fate. We discuss the unsolved problems and future directions of biomaterial stiffness in tissue engineering. (C) 2017 Published by Elsevier Inc.

引用

页码：42 / 48

页数：7

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