Characterization of a novel coronavirus associated with severe acute respiratory syndrome

被引：1926

作者：

Rota, PA ^{[1
]}

Oberste, MS

Monroe, SS

Nix, WA

Campagnoli, R

Icenogle, JP

Peñaranda, S

Bankamp, B

Maher, K

Chen, MH

Tong, SX

Tamin, A

Lowe, L

Frace, M

DeRisi, JL

Chen, Q

Wang, D

Erdman, DD

Peret, TCT

Burns, C

Ksiazek, TG

Rollin, PE

Sanchez, A

Liffick, S

Holloway, B

Limor, J

McCaustland, K

Olsen-Rasmussen, M

Fouchier, R

Günther, S

Osterhaus, ADME

Drosten, C

Pallansch, MA

Anderson, LJ

Bellini, WJ

机构：

[1] Ctr Dis Control, Natl Ctr Infect Dis, Atlanta, GA 30333 USA

[2] Univ Calif San Francisco, Dept Biochem, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Biophys, San Francisco, CA 94143 USA

[4] Erasmus Univ, Dept Virol, NL-3000 DR Rotterdam, Netherlands

[5] Bernhard Nocht Inst Trop Med, Dept Virol, D-20359 Hamburg, Germany

来源：

SCIENCE | 2003年 / 300卷 / 5624期

关键词：

D O I：

10.1126/science.1085952

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.

引用

页码：1394 / 1399

页数：6

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