Lipid mediators of insulin resistance

被引：173
作者：
Holland, William L. [1 ]
Knotts, Trina A. [1 ]
Chavez, Jose A. [1 ]
Wang, Li-Ping [1 ]
Hoehn, Kyle L. [1 ]
Summers, Scott A. [1 ]
机构：
[1] Univ Utah, Sch Med, Dept Internal Med, Div Endocrinol Diabet & Metab, Salt Lake City, UT 84132 USA
来源：
NUTRITION REVIEWS | 2007年 / 65卷 / 06期
关键词：
insulin resistance; lipid; mediators; obesity;
D O I：
10.1301/nr.2007.jun.S39-S46
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Lipid abnormalities such as obesity, increased circulating free fatty acid levels, and excess intramyocellular lipid accumulation are frequently associated with insulin resistance. These observations have prompted investigators to speculate that the accumulation of lipids in tissues not suited for fat storage (e.g., skeletal muscle and liver) is an underlying component of insulin resistance and the metabolic syndrome. We review the metabolic fates of lipids in insulin-responsive tissues and discuss the roles of specific lipid metabolites (e.g., ceramides, GM3 ganglioside, and diacylglycerol) as antagonists of insulin signaling and action.
引用
收藏
页码：S39 / S46
页数：8
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