Evidence for two phenotypes in the metabolism of methotrexate to 7-hydroxymethotrexate in patients with rheumatoid arthritis

被引：9

作者：

Baggott, JE ^{[1
]}

Bridges, SL ^{[1
]}

Morgan, SL ^{[1
]}

机构：

[1] Univ Alabama, Birmingham, AL 35294 USA

来源：

ARTHRITIS AND RHEUMATISM | 2005年 / 52卷 / 01期

关键词：

D O I：

10.1002/art.20742

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：356 / 358

页数：3

共 15 条

[1] Individual variation in hepatic aldehyde oxidase activity [J].

Al-Salmy, HS .

IUBMB LIFE, 2001, 51 (04) :249-253

[2]

Baggott JE, 1998, ARTHRITIS RHEUM, V41, P1407, DOI 10.1002/1529-0131(199808)41:8<1407::AID-ART9>3.0.CO

[3]

2-H

[4] SUBSTRATE-SPECIFICITY OF HUMAN LIVER ALDEHYDE OXIDASE TOWARD SUBSTITUTED QUINAZOLINES AND PHTHALAZINES - A COMPARISON WITH HEPATIC ENZYME FROM GUINEA-PIG, RABBIT, AND BABOON [J].

BEEDHAM, C ;

CRITCHLEY, DJP ;

RANCE, DJ .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1995, 319 (02) :481-490

[5] Pharmacokinetics of low doses of methotrexate in patients with psoriasis over the early period of treatment [J].

Chládek, J ;

Martinková, J ;

Simková, M ;

Vanecková, J ;

Koudelková, V ;

Nozicková, M .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1998, 53 (06) :437-444

[6] Pharmacokinetics and pharmacodynamics of low-dose methotrexate in the treatment of psoriasis [J].

Chládek, J ;

Grim, J ;

Martínková, J ;

Simková, M ;

Vanìèková, J ;

Koudelková, V ;

Noièková, M .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2002, 54 (02) :147-156

[7] HYDROXYLATION OF 4-AMINO-ANTIFOLATES BY PARTIALLY PURIFIED ALDEHYDE OXIDASE FROM RABBIT LIVER [J].

FABRE, G ;

SEITHER, R ;

GOLDMAN, ID .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (08) :1325-1330

[8] Combined oral cyclosporin and methotrexate therapy in patients with rheumatoid arthritis elevates methotrexate levels and reduces 7-hydroxymethotrexate levels when compared with methotrexate alone [J].

Fox, RI ;

Morgan, SL ;

Smith, HT ;

Robbins, BA ;

Choc, MG ;

Baggott, JE .

RHEUMATOLOGY, 2003, 42 (08) :989-994

[9]

JOHNS DG, 1964, LIFE SCI, V74, P1383

[10]

Pollard J.H, 1977, HDB NUMERICAL STAT T

← 1 2 →