Cytokines Activate Src Kinase and Inhibit EGFR-Mediated Repair Mechanisms via Mig6 in Pancreatic Beta Cells

被引:0
|
作者
Fong, Kimberley M. [1 ]
Rezaeizadeh, Alireza [2 ]
Chen, Yi-Chun [1 ]
Fueger, Patrick T. [2 ]
机构
[1] Indiana Univ Sch Med, Cellular & Integrat Physiol, Indianapolis, IN 46202 USA
[2] City Hope Natl Med Ctr, Beckman Res Inst, Mol & Cellular Endocrinol, Duarte, CA USA
来源
FASEB JOURNAL | 2017年 / 31卷
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
715.7
引用
收藏
页数:1
相关论文
共 18 条
  • [1] Mig6 suppresses endogenous repair mechanisms in pancreatic beta cells
    Fueger, P. T.
    Fong, K. M. L.
    DIABETOLOGIA, 2016, 59 : S210 - S210
  • [2] Glucolipotoxicity-induced Mig6 Desensitizes EGFR Signaling and Promotes Pancreatic Beta Cell Death
    Chen, Yi-Chun
    Colvin, E. Scott
    Fueger, Patrick T.
    DIABETES, 2014, 63 : A536 - A536
  • [3] Glucolipotoxic Stress-Induced Mig6 Desensitizes EGFR Signaling and Promotes Pancreatic Beta Cell Death
    Chen, Yi-Chun
    Lutkewitte, Andrew J.
    Basavarajappa, Halesha D.
    Fueger, Patrick T.
    METABOLITES, 2023, 13 (05)
  • [4] PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells
    Siu, Allan
    Virtanen, Carl
    Jongstra, Jan
    ONCOTARGET, 2011, 2 (12) : 1134 - 1144
  • [5] A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation
    Frosi, Yuri
    Anastasi, Sergio
    Ballaro, Costanza
    Varsano, Giulia
    Castellani, Loriana
    Maspero, Elena
    Polo, Simona
    Alema, Stefano
    Segatto, Oreste
    JOURNAL OF CELL BIOLOGY, 2010, 189 (03): : 557 - 571
  • [6] Mitogen-inducible Gene 6 Accelerates the Progression to Diabetes by Inhibiting EGFR-Mediated Repair Mechanisms
    Fong, Kimberley M.
    Fueger, Patrick T.
    FASEB JOURNAL, 2016, 30
  • [7] Proinflammatory cytokines activate phospholipase A2, inhibit insulin secretion and induce apoptosis in pancreatic beta-cells.
    Chen, M
    Wolf, BA
    DIABETES, 1996, 45 : 1159 - 1159
  • [8] The mitogenic effect of Gas6 on pancreatic beta cells is mediated via the receptor tyrosine kinase Axl
    Haase, T. N.
    Gustafsson, A.
    Nalla, A.
    Ringholm, L.
    Damm, P.
    Mathiesen, E. R.
    Dahlback, B.
    Billestrup, N.
    Nielsen, J. H.
    DIABETOLOGIA, 2014, 57 : S173 - S174
  • [9] Effect of Src inhibition on STAT3-mediated interleukin-6 responses in pancreatic beta cells
    Russell, M. A.
    Morgan, N. G.
    DIABETIC MEDICINE, 2014, 31 : 33 - 33
  • [10] Retinoids inhibit adhesion to laminin in human pancreatic carcinoma cells via the alpha(6)beta(1)-integrin receptor
    Rosewicz, S
    Wollbergs, K
    VonLampe, B
    Matthes, H
    Kaiser, A
    Riecken, EO
    GASTROENTEROLOGY, 1997, 112 (02) : 532 - 542