The renin-angiotensin system in the bovine utero-placental unit

被引:0
作者
Nielsen, AH [1 ]
Schauser, KH [1 ]
Winther, H [1 ]
Dantzer, V [1 ]
Poulsen, K [1 ]
机构
[1] Royal Vet & Agr Univ, Dept Anat & Physiol, DK-1870 Frederiksberg C, Denmark
关键词
D O I
暂无
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Renin, angiotensin converting enzyme, and angiotensin II receptors are expressed in the bovine utero-placental unit, indicating the presence of a local renin-angiotensin system (RAS). Angiotensin II receptors of type AT(1) and AT(2) as well as non-AT(1)/non-AT(2) binding sites were identified. The expression of both renin and the angiotensin II receptor types in the bovine utero-placental unit differs from that in humans. This fact is probably related to differences in placental architecture. The RAS in the bovine utero-placental unit might be important for growth processes in the endometrium and for placentation. It might also participate in the regulation of the utero-placental blood flow and secretion of hormones. Disturbances in the utero-placental RAS might cause a reduced utero-placental blood flow, intrauterine growth retardation and intrauterine death.
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页码:153 / 156
页数:4
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