The epidemiology of rotavirus disease in under-five-year-old children hospitalized with acute diarrhea in central Uganda, 2012-2013

被引：14

作者：

Bwogi, Josephine ^{[1
,2
]}

Malamba, Samuel ^{[1
]}

Kigozi, Brian ^{[1
]}

Namuwulya, Prossy ^{[1
]}

Tushabe, Phionah ^{[2
]}

Kiguli, Sarah ^{[2
]}

Byarugaba, Denis Karuhize ^{[3
]}

Desselberger, Ulrich ^{[4
]}

Iturriza-Gomara, Miren ^{[5
]}

Karamagi, Charles ^{[2
]}

机构：

[1] Uganda Virus Res Inst, 51-59 Nakiwogo Rd,POB 49, Entebbe, Uganda

[2] Makerere Univ, Dept Paediat & Child Hlth, Coll Hlth Sci, POB 7072, Kampala, Uganda

[3] Makerere Univ, Dept Microbiol, Coll Vet Med & Biosecur, POB 7072, Kampala, Uganda

[4] Univ Cambridge, Dept Med, Cambridge CB2 0QQ, England

[5] Univ Liverpool, Inst Infect & Global Hlth, Dept Clin Infect Microbiol & Immunol, Ronald Ross Bldg,West Derby St, Liverpool L69 7BE, Merseyside, England

来源：

ARCHIVES OF VIROLOGY | 2016年 / 161卷 / 04期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

Rotavirus; Genotyping; Mixed infections; Reassortment; Food hygiene; Zoonotic transmission; RISK-FACTORS; PREVALENCE; VACCINATION; INFECTION; MORTALITY; GENOTYPES; YOUNGER; STRAIN;

D O I：

10.1007/s00705-015-2742-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A cross-sectional study was undertaken during 2012-2013 to determine the prevalence, strains and factors associated with rotavirus infection among under-5-year-old children hospitalized with acute diarrhea in Uganda. Rotaviruses were detected in 37 % (263/712) of the children. The most prevalent strains were G9P[8] (27 %, 55/204) and G12P[4] (18.6 %, 38/204). Mixed infections were detected in 22.5 % (46/204) of the children. The study suggests that consumption of raw vegetables (OR = 1.45, 95 % CI = 1.03-2.03) and family ownership of dogs (OR = 1.9, 95 % CI = 1.04-3.75) increases the risk of rotavirus infection. The study findings will be used to assess the impact of RV vaccination in Uganda.

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收藏

页码：999 / 1003

页数：5

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