Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma

被引：74

作者：

Gu, Ying ^{[1
,2
]}

Zhang, Jiawei ^{[1
,2
]}

Ma, Xiaoxiao ^{[1
,2
,3
]}

Kim, Byung-Wook ^{[1
,2
,3
]}

Wang, Hailong ^{[1
,2
]}

Li, Jinfan ^{[11
]}

Pan, Yi ^{[12
]}

Xu, Yang ^{[9
,10
]}

Ding, Lili ^{[1
,2
]}

Yang, Lu ^{[6
]}

Guo, Chao ^{[6
]}

Wu, Xiwei ^{[6
]}

Wu, Jun ^{[8
]}

Wu, Kirk ^{[1
,2
]}

Gan, Xiaoxian ^{[1
,2
]}

Li, Gang ^{[1
,2
]}

Li, Ling ^{[7
]}

Forman, Stephen J. ^{[3
,4
]}

Chan, Wing-Chung ^{[3
,5
]}

Xu, Rongzhen ^{[9
,10
]}

Huang, Wendong ^{[1
,2
,3
]}

机构：

[1] City Hope Natl Med Ctr, Beckman Res Inst, Mol & Cellular Biol Canc Program, Duarte, CA 91010 USA

[2] City Hope Natl Med Ctr, Beckman Res Inst, Dept Diabet Complicat & Metab, Duarte, CA 91010 USA

[3] City Hope Natl Med Ctr, Beckman Res Inst, Irell & Manella Grad Sch Biol Sci, Duarte, CA 91010 USA

[4] City Hope Natl Med Ctr, Beckman Res Inst, Dept Hematol & Hematopoiet Cell Transplant, Duarte, CA 91010 USA

[5] City Hope Natl Med Ctr, Beckman Res Inst, Dept Pathol, Duarte, CA 91010 USA

[6] City Hope Natl Med Ctr, Beckman Res Inst, Integrat Genom Core, Duarte, CA 91010 USA

[7] City Hope Natl Med Ctr, Beckman Res Inst, Div Hematopoiet Stem Cell & Leukemia Res, Duarte, CA 91010 USA

[8] City Hope Natl Med Ctr, Beckman Res Inst, Div Comparat Med, Duarte, CA 91010 USA

[9] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Hematol, Hangzhou 310009, Zhejiang, Peoples R China

[10] Zhejiang Univ, Key Lab Canc Prevent & Intervent, Affiliated Hosp 2, Canc Inst,China Natl Minist Educ,Sch Med, Hangzhou 310009, Zhejiang, Peoples R China

[11] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Pathol, Hangzhou 310009, Zhejiang, Peoples R China

[12] Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Dept Pathol, Tianjin 300060, Peoples R China

来源：

CANCER CELL | 2017年 / 32卷 / 01期

基金：

中国国家自然科学基金;

关键词：

KINASE-II; CRITICAL REGULATOR; ACTIVATION; PHOSPHORYLATION; APOPTOSIS; TRANSFORMATION; DERIVATIVES; BIOGENESIS; REGRESSION; ONCOGENES;

D O I：

10.1016/j.ccell.2017.06.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although high c-Myc protein expression is observed alongside MYC amplification in some cancers, in most cases protein overexpression occurs in the absence of gene amplification, e. g., T cell lymphoma (TCL). Here, Ca2+/calmodulin-dependent protein kinase II gamma (CAMKII gamma) was shown to stabilize the c-Myc protein by directly phosphorylating it at serine 62 (S62). Furthermore, CAMKII gamma was shown to be essential for tumor maintenance. Inhibition of CAMKII gamma with a specific inhibitor destabilized c-Myc and reduced tumor burden. Importantly, high CAMKII gamma levels in patient TCL specimens correlate with increased c-Myc and pS62-c-Myc levels. Together, the CAMKII gamma:c-Myc axis critically influences the development and maintenance of TCL and represents a potential therapeutic target for TCL.

引用

页码：115 / +

页数：21

共 54 条

[1] The γ isoform of CaM kinase II controls mouse egg activation by regulating cell cycle resumption [J].

Backs, Johannes ;

Stein, Paula ;

Backs, Thea ;

Duncan, Francesca E. ;

Grueter, Chad E. ;

McAnally, John ;

Qi, Xiaoxia ;

Schultz, Richard M. ;

Olson, Eric N. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (01) :81-86

[2] Chimeric Antigen Receptor Therapy for Cancer [J].

Barrett, David M. ;

Singh, Nathan ;

Porter, David L. ;

Grupp, Stephan A. ;

June, Carl H. .

ANNUAL REVIEW OF MEDICINE, VOL 65, 2014, 65 :333-347

[3] A role for CaMKII in T cell memory [J].

Bui, JD ;

Calbo, S ;

Hayden-Martinez, K ;

Kane, LP ;

Gardner, P ;

Hedrick, SM .

CELL, 2000, 100 (04) :457-467

[4] Expression Profiles of MYC Protein and MYC Gene Rearrangement in Lymphomas [J].

Chisholm, Karen M. ;

Bangs, Charles D. ;

Bacchi, Carlos E. ;

Molina-Kirsch, Hernan ;

Cherry, Athena ;

Natkunam, Yasodha .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2015, 39 (03) :294-303

[5] Addiction to multiple oncogenes can be exploited to prevent the emergence of therapeutic resistance [J].

Choi, Peter S. ;

Li, Yulin ;

Felsher, Dean W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (32) :E3316-E3324

[6] THE MYC ONCOGENE - ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION [J].

COLE, MD .

ANNUAL REVIEW OF GENETICS, 1986, 20 :361-384

[7] Transcription-independent functions of MYC: regulation of translation and DNA replication [J].

Cole, Michael D. ;

Cowling, Victoria H. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (10) :810-815

[8]

Colomer J., 2007, V45, P169

[9] Anaplastic lymphoma kinase inhibitors [J].

Crescenzo, Ramona ;

Inghirami, Giorgio .

CURRENT OPINION IN PHARMACOLOGY, 2015, 23 :39-44

[10] Crosstalk Between c-Myc and Ribosome in Ribosomal Biogenesis and Cancer [J].

Dai, Mu-Shui ;

Lu, Hua .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2008, 105 (03) :670-677

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