Cytomegalovirus infection in lung transplant recipients

被引：19

作者：

Almaghrabi, Reem S. ^{[1
]}

Omrani, Ali S. ^{[1
]}

Memish, Ziad A. ^{[2
,3
,4
]}

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Infect Dis Sect, Dept Med, Riyadh, Saudi Arabia

[2] Prince Mohammed Bin Abdulaziz Hosp, Res Dept, Minist Hlth, Riyadh, Saudi Arabia

[3] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia

[4] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA

来源：

EXPERT REVIEW OF RESPIRATORY MEDICINE | 2017年 / 11卷 / 05期

关键词：

Cytomegalovirus; CMV; lung transplant; immune compromised; pneumonitis; HEMATOPOIETIC-CELL TRANSPLANTATION; REAL-TIME PCR; BRONCHIOLITIS-OBLITERANS-SYNDROME; SINGLE-CENTER EXPERIENCE; SOLID-ORGAN; RESISTANT CYTOMEGALOVIRUS; CMV INFECTION; IMMUNE-RESPONSE; VALGANCICLOVIR PROPHYLAXIS; INTRAVENOUS GANCICLOVIR;

D O I：

10.1080/17476348.2017.1317596

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Introduction: Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality in solid organ transplant (SOT) patients. Lung transplant recipients are particularly at risk given the intense immunosuppression required.Areas covered: The Detailed review of the literature related to CMV infection, its direct and indirect effect on lung allograft function, as well as diagnosis, immune monitoring, treatment options and prevention strategies.Expert commentary: In lung transplant recipients, CMV infection is associated with pro-inflammatory and immune inhibitory effects that increase the risk of graft dysfunction and loss. Diagnosis of CMV infection remains challenging. Treatment options remain relatively limited.

引用

页码：377 / 383

页数：7

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