Enhancements of the production of bilirubin and the expression of -globin by carbon monoxide during erythroid differentiation

被引：7

作者：

Mu, Anfeng ^{[1
]}

Li, Ming ^{[2
]}

Tanaka, Masakazu ^{[2
]}

Adachi, Yasushi ^{[3
]}

Tran Tien Tai ^{[1
,4
]}

Pham Hieu Liem ^{[1
,5
]}

Izawa, Shingo ^{[1
]}

Furuyama, Kazumichi ^{[6
]}

Taketani, Shigeru ^{[1
,2
]}

机构：

[1] Kyoto Inst Technol, Dept Biotechnol, Kyoto, Japan

[2] Kansai Med Univ, Unit Res Complex, Hirakara, Osaka, Japan

[3] Toyooka Hosp, Dept Pathol, Toyooka, Hyogo, Japan

[4] Pham Ngoc Thach Univ Med, Dept Physiol Pathophysiol & Immunol, Ho Chi Minh, Vietnam

[5] Pham Ngoc Thach Univ Med, Dept Plast & Aesthet Surg, Ho Chi Minh, Vietnam

[6] Iwate Med Univ, Dept Mol Biochem, Yahaba, Iwate, Japan

来源：

FEBS LETTERS | 2016年 / 590卷 / 10期

关键词：

bilirubin; bone marrow cells; carbon monoxide; heme biosynthesis; hemoglobin; HEME OXYGENASE-1; MESSENGER-RNA; BETA-GLOBIN; IRON; RED; TRANSCRIPTION; ACCUMULATION; ROLES;

D O I：

10.1002/1873-3468.12178

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heme is degraded by heme oxygenase to form iron, carbon monoxide (CO), and biliverdin. However, information about the catabolism of heme in erythroid cells is limited. In this study, we showed the production and export of bilirubin in murine erythroleukemia (MEL) cells. The production of bilirubin by MEL cells was enhanced when heme synthesis was induced. When mouse bone marrow cells were induced with erythropoietin to differentiate into erythroid cells, the synthesis of bilirubin increased. The expression of -globin was enhanced by CO at the transcriptional level. These results indicate that constant production of CO from heme regulates erythropoiesis.

引用

页码：1447 / 1454

页数：8

共 29 条

[1]

Alam J, 2004, ANTIOXID REDOX SIGN, V6, P924, DOI 10.1089/ars.2004.6.924

[2] Heme-Oxygenases during Erythropoiesis in K562 and Human Bone Marrow Cells [J].