Increased long-term risk of major adverse cardiovascular events in patients with carbon monoxide poisoning: A population-based study in Taiwan

被引:16
作者
Wong, Chung-Shun [1 ,2 ,3 ]
Lin, Ying-Chin [4 ,5 ]
Sung, Li-Chin [6 ]
Chen, Tzu-Ting [7 ]
Ma, Hon-Ping [1 ,3 ]
Hsu, Yung-Ho [8 ,9 ]
Tsai, Shin-Han [1 ,3 ,10 ]
Lin, Yuh-Feng [2 ,8 ,9 ]
Wu, Mei-Yi [7 ,8 ,9 ]
机构
[1] Taipei Med Univ, Shuang Ho Hosp, Dept Emergency Med, Taipei, Taiwan
[2] Taipei Med Univ, Coll Med, Grad Inst Clin Med, Taipei, Taiwan
[3] Taipei Med Univ, Coll Med, Sch Med, Dept Emergency Med, Taipei, Taiwan
[4] Taipei Med Univ, Shuang Ho Hosp, Dept Family Med, Taipei, Taiwan
[5] Taipei Med Univ, Sch Med, Coll Med, Dept Family Med, Taipei, Taiwan
[6] Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Cardiol, Taipei, Taiwan
[7] Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan
[8] Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Nephrol, Taipei, Taiwan
[9] Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med, Taipei, Taiwan
[10] Taipei Med Univ, Coll Publ Hlth & Nutr, Taipei, Taiwan
来源
PLOS ONE | 2017年 / 12卷 / 04期
关键词
MORTALITY; MODERATE;
D O I
10.1371/journal.pone.0176465
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Carbon monoxide (CO) poisoning may cause toxicity to the cardiovascular system. However, the association between CO poisoning and the risk of major adverse cardiovascular events (MACE) remains unestablished. We investigated the incidence of MACE after CO poisoning in Taiwan and evaluated whether CO-poisoned individuals had a higher risk of MACE than did the general population. Methods Using Taiwan's National Health Insurance Research Database (NHIRD) during 2005-2013, a nationwide population-based cohort study was conducted among patients who experienced CO poisoning between 2005 and 2013. CO poisoning was defined according to the International Classification of Diseases, Ninth Revision, Clinical Modification codes. The study cohort comprised patients with CO poisoning between 2005 and 2010 (N = 13,939). Each patient was matched according to age, sex and index date with four randomly selected controls from the comparison cohort (N = 55,756). All patients were followed from the study date until MACE development, death, or the end of 2013. The hazard ratios for MACE were compared between the two cohorts by using Cox proportional hazards regressions analyses. Results Incident cases of MACE were identified from the NHIRD. After adjustment for potential confounders, the study cohort was independently associated with a higher MACE risk (adjusted hazard ratio, 2.00; 95% confidence interval, 1.83-2.18). Conclusion This population-based cohort study indicated that patients with CO poisoning have a higher risk of MACE than do individuals without CO poisoning.
引用
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页数:9
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