Cellular Cyborgs: On the Precipice of a Drug Delivery Revolution

被引：28
作者：
Ding, Song [1 ]
O'Banion, Colin P. [1 ]
Welfare, Joshua G. [2 ]
Lawrence, David S. [1 ,2 ,3 ]
机构：
[1] Univ N Carolina, UNC Eshelman Sch Pharm, Div Chem Biol & Med Chem, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA
来源：
CELL CHEMICAL BIOLOGY | 2018年 / 25卷 / 06期
关键词：
RED-BLOOD-CELLS; MONOCYTE-MEDIATED DELIVERY; TARGETED DELIVERY; STEM-CELL; LOADED ERYTHROCYTES; CIRCULATORY CELLS; GENE-THERAPY; MEMBRANE; PROTEIN; PLATELETS;
D O I：
10.1016/j.chembiol.2018.03.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell-based drug delivery systems offer the prospect of biocompatibility, large-loading capacity, long in vivo lifespan, and active targeting of diseased sites. However, these opportunities are offset by an array of challenges, including safeguarding the integrity of the drug cargo and the cellular host, as well as ensuring that drug release occurs at the appropriate time and place. Emerging strategies that address these, and related, issues, are described herein.
引用
收藏
页码：648 / 658
页数：11
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  • [81] Surface-Engineering of Red Blood Cells as Artificial Antigen Presenting Cells Promising for Cancer Immunotherapy
    Sun, Xiaoqi
    Han, Xiao
    Xu, Ligeng
    Gao, Min
    Xu, Jun
    Yang, Rong
    Liu, Zhuang
    [J]. SMALL, 2017, 13 (40)
  • [82] Surface Functionalization of Living Cells with Multilayer Patches
    Swiston, Albert J.
    Cheng, Connie
    Um, Soong Ho
    Irvine, Darrell J.
    Cohen, Robert E.
    Rubner, Michael F.
    [J]. NANO LETTERS, 2008, 8 (12) : 4446 - 4453
  • [83] Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    Takahashi, Kazutoshi
    Yamanaka, Shinya
    [J]. CELL, 2006, 126 (04) : 663 - 676
  • [84] Cell or Cell Membrane-Based Drug Delivery Systems
    Tan, Songwei
    Wu, Tingting
    Zhang, Dan
    Zhang, Zhiping
    [J]. THERANOSTICS, 2015, 5 (08): : 863 - 881
  • [85] RETRACTED: Quantitative Analysis of Transcranial and Intraparenchymal Light Penetration in Human Cadaver Brain Tissue (Retracted article. See vol. 47, pg. 466, 2015)
    Tedford, Clark E.
    DeLapp, Scott
    Jacques, Steven
    Anders, Juanita
    [J]. LASERS IN SURGERY AND MEDICINE, 2015, 47 (04) : 312 - 322
  • [86] The role of platelets in inflammation
    Thomas, Mark R.
    Storey, Robert F.
    [J]. THROMBOSIS AND HAEMOSTASIS, 2015, 114 (03) : 449 - 458
  • [87] Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy
    Tromberg, BJ
    Shah, N
    Lanning, R
    Cerussi, A
    Espinoza, J
    Pham, T
    Svaasand, L
    Butler, J
    [J]. NEOPLASIA, 2000, 2 (1-2): : 26 - 40
  • [88] Neutrophils in Cancer: Two Sides of the Same Coin
    Uribe-Querol, Eileen
    Rosales, Carlos
    [J]. JOURNAL OF IMMUNOLOGY RESEARCH, 2015, 2015
  • [89] Erythrocytes as Carriers for Drug Delivery in Blood Transfusion and Beyond
    Villa, Carlos H.
    Cines, Douglas B.
    Siegel, Don L.
    Muzykantov, Vladimir
    [J]. TRANSFUSION MEDICINE REVIEWS, 2017, 31 (01) : 26 - 35
  • [90] Villa CH, 2015, THER DELIV, V6, P795, DOI [10.4155/tde.15.34, 10.4155/TDE.15.34]
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