Cellular Cyborgs: On the Precipice of a Drug Delivery Revolution

被引：28
作者：
Ding, Song [1 ]
O'Banion, Colin P. [1 ]
Welfare, Joshua G. [2 ]
Lawrence, David S. [1 ,2 ,3 ]
机构：
[1] Univ N Carolina, UNC Eshelman Sch Pharm, Div Chem Biol & Med Chem, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA
来源：
CELL CHEMICAL BIOLOGY | 2018年 / 25卷 / 06期
关键词：
RED-BLOOD-CELLS; MONOCYTE-MEDIATED DELIVERY; TARGETED DELIVERY; STEM-CELL; LOADED ERYTHROCYTES; CIRCULATORY CELLS; GENE-THERAPY; MEMBRANE; PROTEIN; PLATELETS;
D O I：
10.1016/j.chembiol.2018.03.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell-based drug delivery systems offer the prospect of biocompatibility, large-loading capacity, long in vivo lifespan, and active targeting of diseased sites. However, these opportunities are offset by an array of challenges, including safeguarding the integrity of the drug cargo and the cellular host, as well as ensuring that drug release occurs at the appropriate time and place. Emerging strategies that address these, and related, issues, are described herein.
引用
收藏
页码：648 / 658
页数：11
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