Synthesis and antimicrobial activities of novel 1,5-diaryl pyrazoles

被引：147
作者：
Ragavan, R. Venkat [1 ,2 ]
Vijayakumar, V. [1 ]
Kumari, N. Suchetha [3 ]
机构：
[1] VIT Univ, Div Organ Chem, Sch Adv Sci, Vellore 632014, Tamil Nadu, India
[2] Syngene Int Pvt Ltd, Bangalore 560099, Karnataka, India
[3] KS Hegde Med Acad, Dept Biochem, Deralakatte 574162, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 03期
关键词：
1,5-Diaryl pyrazoles; 5-(4-Chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxamides; 2-(5-(4-Chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-yl)thiazoles; 4-Piperidine amide pharmacophore; Synthesis; Antibacterial activity; Antifungal activity; ANTIBACTERIAL ACTIVITY; BIOLOGICAL EVALUATION; DERIVATIVES; ANTIFUNGAL; INHIBITORS; POTENT; UREAS;
D O I：
10.1016/j.ejmech.2009.12.042
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel 1,5-diaryl pyrazole derivatives viz. 5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxamides (2a-e, 3, 3a-f), 2-(5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-yl)thiazoles (6a-c,7, 8, 9a-c, 10, 11) were synthesized by varying the active part (amide group) of pyrazole, characterized using lR, H-1 NMR, mass spectral data and screened for their antibacterial activity against Escherichia coli (ATTC-25922), Staphylococcus aureus (ATTC-25923), Pseudomonas aeruginosa (ATTC-27853), Klebsiella pneumonia. Similarly all these compounds were screened for their antifungal activity against Aspergillus flavus (NCIM No. 524), Aspergillus fumigates (NCIM No. 902), Penicillium marneffei and Trichophyton mentagrophytes. interestingly all the synthesized compounds exhibited good antibacterial (except 2a-c, 8, 9a) and antifungal activity (except 2a-c, 6a, 8, 9a). (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：1173 / 1180
页数：8
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