SILICA DIOXIDE NANOFIBER BASED DRUG DELIVERY SYSTEM WITH SUSTAINED RELEASE

被引：0
|
作者：
Tomankova, Hana [1 ]
Rysova, Miroslava [1 ,2 ]
Schneidrova, Marie [3 ]
Sklenarova, Hana [3 ]
机构：
[1] TUL, Inst Nanomat Novel Technol & Innovat CXi, Liberec, Czech Republic
[2] TUL, Inst New Technol & Appl Informat FM, Liberec, Czech Republic
[3] Charles Univ Prague, Fac Pharm Hradec Kralove, Prague, Czech Republic
来源：
11TH INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2019) | 2020年
关键词：
Silica dioxide nanofibers; sustained release; wound healing; antibiotic; topical delivery;
D O I：
10.37904/nanocon.2019.8770
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
We developed a transdermal drug delivery system containing tetracycline as a model antibiotic for wound healing application. Our previous in vitro tests proved no cytotoxic effect nor antibacterial activity of the silica nanofiber based matrix. This study was designed to evaluate biocompatibility of our nanofiber-antibiotic system via reconstructed human skin model, and to confirm sustained release of the incorporated active compound. Further characterization showed that both moisture vapor permeability and enhanced hydrophilicity of the modified nanofibers remained consistent after functionalization. The summarized results proved that this drug delivery system is a perspective solution in potential medicated sustained release patch for wound healing.
引用
收藏
页码：336 / 341
页数：6
相关论文
共 50 条
  • [21] A lipid based depot (DepoFoam® technology) for sustained release drug delivery
    Mantripragada, S
    PROGRESS IN LIPID RESEARCH, 2002, 41 (05) : 392 - 406
  • [22] Structure and release behavior of PMMA/silica composite drug delivery system
    Lin, Mei
    Wang, Haitao
    Meng, Sheng
    Zhong, Wei
    Li, Zhulai
    Cai, Rui
    Chen, Zhuo
    Zhou, Xiaoyu
    Du, Qiangguo
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2007, 96 (06) : 1518 - 1526
  • [23] Preparation and Evaluation of Dexamethasone-Loaded Electrospun Nanofiber Sheets as a Sustained Drug Delivery System
    Lee, Jin Woo
    Lee, Hye Yun
    Park, Seung Hun
    Park, Ji Hoon
    Kim, Jae Ho
    Min, Byoung Hyun
    Kim, Moon Suk
    MATERIALS, 2016, 9 (03):
  • [24] A Review on Research of the Sustained Release Drug Delivery System Based on Magnesium Aluminate Layered Double Hydroxide
    Gou, Guo-jing
    Dong, Li-e
    Bao, Feng-juan
    Wang, Zhi-Yu
    Jiao, Lin
    Huang, Jie
    Sun, Yue
    Xue, Bing
    CHINA FUNCTIONAL MATERIALS TECHNOLOGY AND INDUSTRY FORUM, 2013, 320 : 495 - 504
  • [25] Vesosomal drug delivery system with multi-compartments for controlled and sustained release
    Lee, Deborah
    Song, Seoyoon
    Kim, Suheon
    Lee, Mina
    Kim, Eunsu
    Huh, Yun Suk
    Kim, Sun Min
    Jeon, Tae-Joon
    BIOPHYSICAL JOURNAL, 2023, 122 (03) : 549A - 550A
  • [26] A Microparticle/Hydrogel Combination Drug-Delivery System for Sustained Release of Retinoids
    Gao, Song-Qi
    Maeda, Tadao
    Okano, Kiichiro
    Palczewski, Krzysztof
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2012, 53 (10) : 6314 - 6323
  • [27] Radiosensitization by intratumoral administration of cisplatin in a sustained-release drug delivery system
    Ning, SC
    Yu, N
    Brown, DM
    Kanekal, S
    Knox, SJ
    RADIOTHERAPY AND ONCOLOGY, 1999, 50 (02) : 215 - 223
  • [28] A SUSTAINED-RELEASE DRUG DELIVERY SYSTEM USING CALCIUM ALGINATE BEADS
    BADWAN, AA
    ABUMALOOH, A
    SALLAM, E
    ABUKALAF, A
    JAWAN, O
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1985, 11 (2-3) : 239 - 256
  • [29] Novel sustained release, swellable and bioadhesive gastroretentive drug delivery system for ofloxacin
    Chavanpatil, Mahesh D.
    Jain, Paras
    Chaudhari, Sachin
    Shear, Rajesh
    Vavia, Pradeep R.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 316 (1-2) : 86 - 92
  • [30] Dual sustained release delivery system for multiple route therapy of an antiviral drug
    Ramyadevi, D.
    Sandhya, P.
    DRUG DELIVERY, 2014, 21 (04) : 276 - 292
12345