SILICA DIOXIDE NANOFIBER BASED DRUG DELIVERY SYSTEM WITH SUSTAINED RELEASE

被引：0
|
作者：
Tomankova, Hana [1 ]
Rysova, Miroslava [1 ,2 ]
Schneidrova, Marie [3 ]
Sklenarova, Hana [3 ]
机构：
[1] TUL, Inst Nanomat Novel Technol & Innovat CXi, Liberec, Czech Republic
[2] TUL, Inst New Technol & Appl Informat FM, Liberec, Czech Republic
[3] Charles Univ Prague, Fac Pharm Hradec Kralove, Prague, Czech Republic
来源：
11TH INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2019) | 2020年
关键词：
Silica dioxide nanofibers; sustained release; wound healing; antibiotic; topical delivery;
D O I：
10.37904/nanocon.2019.8770
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
We developed a transdermal drug delivery system containing tetracycline as a model antibiotic for wound healing application. Our previous in vitro tests proved no cytotoxic effect nor antibacterial activity of the silica nanofiber based matrix. This study was designed to evaluate biocompatibility of our nanofiber-antibiotic system via reconstructed human skin model, and to confirm sustained release of the incorporated active compound. Further characterization showed that both moisture vapor permeability and enhanced hydrophilicity of the modified nanofibers remained consistent after functionalization. The summarized results proved that this drug delivery system is a perspective solution in potential medicated sustained release patch for wound healing.
引用
收藏
页码：336 / 341
页数：6
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