Longitudinal Follow-Up of Gross Motor Function in Children with Congenital Zika Virus Syndrome from a Cohort in Rio de Janeiro, Brazil

被引:6
作者
Hamanaka, Tatiana [1 ]
Ribeiro, Carla Trevisan M. [1 ]
Pone, Sheila [1 ]
Gomes, Saint Clair [1 ]
Nielsen-Saines, Karin [2 ]
Brickley, Elizabeth B. [3 ]
Moreira, Maria Elisabeth [1 ]
Pone, Marcos [1 ]
机构
[1] Oswaldo Cruz Fdn IFF Fiocruz, Natl Inst Women Children & Adolescents Hlth Ferna, BR-22250020 Rio De Janeiro, Brazil
[2] Univ Calif Los Angeles, David Geffen Sch Med, 10833 Le Conte Ave, Los Angeles, CA 90095 USA
[3] London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England
来源
VIRUSES-BASEL | 2022年 / 14卷 / 06期
基金
欧盟地平线“2020”; 英国惠康基金;
关键词
zika virus; congenital zika virus syndrome; motor development; CEREBRAL-PALSY;
D O I
10.3390/v14061173
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Knowledge of how congenital Zika syndrome (CZS) impacts motor development of children longitudinally is important to guide management. The objective of the present study was to describe the evolution of gross motor function in children with CZS in a Rio de Janeiro hospital. In children with CZS without arthrogryposis or other congenital osteoarticular malformations who were followed in a prospective cohort study, motor performance was evaluated at two timepoints using the Gross Motor Function Classification System (GMFCS) and the Gross Motor Function Measurement test (GMFM-88). Among 74 children, at the baseline evaluation, the median age was 13 (8-24) months, and on follow-up, 28 (24-48) months. According to GMFCS at the second timepoint, 6 children were classified as mild, 11 as moderate, and 57 as severe. In the GMFM-88 assessment, children in the severe group had a median score of 10.05 in the baseline evaluation and a follow-up score of 12.40, the moderate group had median scores of 25.60 and 29.60, and the mild group had median scores of 82.60 and 91.00, respectively. Although a small developmental improvement was observed, the motor impairment of children was mainly consistent with severe cerebral palsy. Baseline motor function assessments were predictive of prognosis.
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页数:9
相关论文
共 33 条
[21]   Association Between Neonatal Neuroimaging and Clinical Outcomes in Zika-Exposed Infants From Rio de Janeiro, Brazil [J].
Pool, Kara-Lee ;
Adachi, Kristina ;
Karnezis, Stellios ;
Salamon, Noriko ;
Romero, Tahmineh ;
Nielsen-Saines, Karin ;
Pone, Sheila ;
Boechat, Marcia ;
Aibe, Mitsue ;
da Silva, Tallita Gomes ;
Martins Ribeiro, Carla Trevisan ;
Boechat, Ines ;
Brasil, Patricia ;
Zin, Andrea ;
Tsui, Irena ;
Gaw, Stephanie L. ;
Daltro, Pedro ;
Ribeiro, Bianca Guedes ;
Fazecas, Tatiana ;
Celso Hygino da Cruz, L. ;
Nogueira, Renata ;
Vasconcelos, Zilton ;
Pereira, Jose Paulo, Jr. ;
Salles, Tania Saad ;
Barbosa, Claudia Neves ;
Chen, Weiqiang ;
Foo, Suan-Sin ;
Jung, Jae ;
Moreira, Maria Elisabeth ;
Pone, Marcos .
JAMA NETWORK OPEN, 2019, 2 (07)
[22]   Gross motor function in children with Congenital Zika Syndrome from Rio de Janeiro, Brazil [J].
Ribeiro, Carla Trevisan M. ;
Hamanaka, Tatiana ;
Pone, Sheila ;
Aibe, Mitsue Senra ;
Gomes, Saint Clair ;
Nielsen-Saines, Karin ;
Brickley, Elizabeth B. ;
Moreira, Maria Elisabeth ;
Pone, Marcos .
EUROPEAN JOURNAL OF PEDIATRICS, 2022, 181 (02) :783-788
[23]   Prognosis or gross motor function in cerebral palsy - Creation of motor development curves [J].
Rosenbaum, PL ;
Walter, SD ;
Hanna, SE ;
Palisano, RJ ;
Russell, DJ ;
Raina, P ;
Wood, E ;
Bartlett, DJ ;
Galuppi, BE .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (11) :1357-1363
[24]   Neurological manifestations of congenital Zika virus infection [J].
Saad, Tania ;
PennaeCosta, Alessandra Augusta ;
de Goes, Fernanda Veiga ;
de Freitas, Marcela ;
de Almeida, Julia Valeriano ;
de Santa Ignez, Lucio Jose ;
Amancio, Ana Paula ;
Alvim, Renata Joviano ;
Antunes Kramberger, Ludmilla Athayde .
CHILDS NERVOUS SYSTEM, 2018, 34 (01) :73-78
[25]  
SAB/SAS/SRJ, 2018, PLANO EXECUCAO ESTRA
[26]  
SES-Secretaria de Estado de Saude do Rio de Janeiro, 2019, SUBS VIG SAUD SUP VI
[27]  
Shonkoff J., 2000, NEURONS NEIGHBOURHOO, DOI [DOI 10.17226/9824, 10.17226/9824]
[28]   Pediatric neurodevelopment by prenatal Zika virus exposure: a cross-sectional study of the Microcephaly Epidemic Research Group Cohort [J].
Sobral da Silva, Paula Fabiana ;
Eickmann, Sophie Helena ;
de Alencar Ximenes, Ricardo Arraes ;
Montarroyos, Ulisses Ramos ;
Lima, Marilia de Carvalho ;
Turchi Martelli, Celina M. ;
Barreto de Araujo, Thalia Velho ;
Brickley, Elizabeth B. ;
Rodrigues, Laura Cunha ;
da Silva Pastich Goncalves, Fabiana Cristina Lima ;
Costa Gomes Carvalho, Maria Durce ;
de Souza, Wayner Vieira ;
de Barros Miranda-Filho, Democrito .
BMC PEDIATRICS, 2020, 20 (01)
[29]   Description of 13 Infants Born During October 2015-January 2016 With Congenital Zika Virus Infection Without Microcephaly at Birth - Brazil [J].
van der Linden, Vanessa ;
Pessoa, Andre ;
Dobyns, William ;
Barkovich, A. James ;
van der Linden, Helio, Jr. ;
Rolim Filho, Epitacio Leite ;
Ribeiro, Erlane Marques ;
Leal, Mariana de Carvalho ;
de Aratijo Coimbra, Pablo Picasso ;
Viana Vasco Araglo, Maria de Fatima ;
Vercosa, Islane ;
Ventura, Camila ;
Ramos, Regina Coeli ;
Sousa Cruz, Danielle Di Cavalcanti ;
Cordeiro, Marli Tenorio ;
Ribeiro Mota, Vivian Maria ;
Dott, Mary ;
Hillard, Christina ;
Moore, Cynthia A. .
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2016, 65 (47) :1343-1348
[30]   Early Gross Motor Development Among Brazilian Children with Microcephaly Born Right After Zika Virus Infection Outbreak [J].
Ventura, Paloma A. ;
Lage, Maria-Lucia C. ;
de Carvalho, Alessandra L. ;
Fernandes, Adriana S. ;
Taguchi, Tania B. ;
Nascimento-Carvalho, Cristiana M. .
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS, 2020, 41 (02) :134-140