Mast Cells and the Pancreas in Human Type 1 and Type 2 Diabetes

被引：5
作者：
Masini, Matilde [1 ]
Suleiman, Mara [2 ]
Novelli, Michela [1 ]
Marselli, Lorella [2 ]
Marchetti, Piero [2 ]
De Tata, Vincenzo [1 ,3 ]
机构：
[1] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Via Roma,55 Scuola Med, I-56126 Pisa, Italy
[2] Univ Pisa, Pancreat Islet Lab, Dept Clin & Expt Med, I-56124 Pisa, Italy
[3] Univ Pisa, Ctr Interdipartimentale Microscopia Elettron CIME, I-56126 Pisa, Italy
来源：
CELLS | 2021年 / 10卷 / 08期
基金：
欧盟地平线“2020”;
关键词：
mast cells; type; 1; diabetes; 2; pancreatic beta cells; insulin secretion; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; HOST-DEFENSE; BETA-CELLS; INFLAMMATION; TRYPTASE; DISEASE; ISLETS; IGE; PATHOGENESIS;
D O I：
10.3390/cells10081875
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mast cells are highly differentiated, widely distributed cells of the innate immune system, that are currently considered as key regulators of both innate and adaptive immunity. Mast cells play a key role in health and survival mechanisms, especially as sentinel cells that can stimulate protective immune responses. On the other hand, it has been shown that mast cells are involved in the pathogenesis of several diseases, and recently a possible pathogenetic role of mast cells in diabetes has been proposed. In this review we summarize the evidence on the increased presence of mast cells in the pancreas of subjects with type 1 diabetes, which is due to the autoimmune destruction of insulin secreting beta cells, and discuss the differences with type 2 diabetes, the other major form of diabetes. In addition, we describe some of the pathophysiological mechanisms through which mast cells might exert their actions, which could be targeted to potentially protect the beta cells in autoimmune diabetes.
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页数：11
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