Synthetic studies on cyathins:: Enantioselective total synthesis of (+)-allocyathin B2

被引：65

作者：

Takano, M ^{[1
]}

Umino, A ^{[1
]}

Nakada, M ^{[1
]}

机构：

[1] Waseda Univ, Sch Sci & Engn, Dept Chem, Shinjuku Ku, Tokyo 1698555, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 26期

关键词：

D O I：

10.1021/ol048010i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[Graphics] The enantioselective total synthesis of (+)-allocyathin B-2 has been achieved. Our approach features a convergent enantioselective construction of the 5-6-7 tricyclic core system using the originally developed chiral building blocks via asymmetric catalysis, the intramolecular aldol reaction in high yield, successful samarium diiodide-mediated ring expansion, and a newly developed double-bond installation method.

引用

页码：4897 / 4900

页数：4

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