Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine

被引：58
作者：
Alarcon, E. I. [1 ]
Vulesevic, B. [1 ]
Argawal, A. [1 ]
Ross, A. [1 ]
Bejjani, P. [1 ]
Podrebarac, J. [1 ]
Ravichandran, R. [2 ]
Phopase, J. [2 ]
Suuronen, E. J. [1 ]
Griffith, M. [3 ]
机构：
[1] Univ Ottawa, Inst Heart, Div Cardiac Surg, Bionanomat Chem & Engn Lab, 40 Ruskin St,Rm H5229, Ottawa, ON, Canada
[2] Linkoping Univ, Dept Phys Chem & Biol, SE-58183 Linkoping, Sweden
[3] Linkoping Univ, Integrat Regenerat Med Ctr, Dept Clin & Expt Med, SE-58183 Linkoping, Sweden
来源：
NANOSCALE | 2016年 / 8卷 / 12期
基金：
瑞典研究理事会; 加拿大自然科学与工程研究理事会;
关键词：
ESCHERICHIA-COLI; ANTIBACTERIAL ACTION; PSEUDOMONAS; RESISTANCE; TOXICITY; INFLAMMATION; BACTERIAL; IONS; INFECTION; KINETICS;
D O I：
10.1039/c6nr01339b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Despite the broad anti-microbial and anti-inflammatory properties of silver nanoparticles (AgNPs), their use in bioengineered corneal replacements or bandage contact lenses has been hindered due to their intense yellow coloration. In this communication, we report the development of a new strategy to pre-stabilize and incorporate AgNPs with different colours into collagen matrices for fabrication of corneal implants and lenses, and assessed their in vitro and in vivo activity.
引用
收藏
页码：6484 / 6489
页数：6
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