Betacyanins from Portulaca oleracea L. ameliorate cognition deficits and attenuate oxidative damage induced by D-galactose in the brains of senescent mice

被引:62
作者
Wang, Chang-Quan [1 ]
Yang, Gui-Qin [2 ]
机构
[1] Shandong Univ Technol, Coll Life Sci, Zibo 255049, Shandong, Peoples R China
[2] Chinese Med Hosp Zhangdian Dist, Zibo 255035, Shandong, Peoples R China
关键词
Cognition; D-galactose; Mice; Oxidative stress; Portulaca oleracea L; MUSCLE RELAXANT ACTION; INCREASED RESISTANCE; ANTIOXIDANT ACTIVITY; BETALAINS; ACID; BETANIN; EXTRACT; FOOD; CHEMOPREVENTION; IMPAIRMENT;
D O I
10.1016/j.phymed.2009.09.006
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
This experiment was designed to assess the protective effect of betacyanins from Portulaca oleracea L against the D-galactose (D-gal)-induced neurotoxicity in mice. Betacyanins from Portulaca oleracea markedly reversed the D-gal-induced learning and memory impairments, as measured by behavioral tests. The activities of superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) in D-gal-treated mice were enhanced, while the content of the lipid peroxidation product malondialdehyde (MDA) was decreased by betacyanin administration. Furthermore, significant negative correlations were found between mouse latency in finding the platform and the activities of SOD, CAT GR and GPx in the mouse brain, but the level of MDA correlated positively with the latency. These results suggest that the neuroprotective effect of betacyanins against D-gal-induced neurotoxicity might be caused, at least in part, by an increase in the activities of antioxidant enzymes with a reduction in lipid peroxidation. In comparison with vitamin C (VC), the betacyanins had a more pronounced effect on ameliorating cognition deficits in mice. (C) 2009 Elsevier GmbH. All rights reserved.
引用
收藏
页码:527 / 532
页数:6
相关论文
共 47 条
[41]   Behavioural study of the D-galactose induced aging model in C57BL/6J mice [J].
Wei, HF ;
Li, L ;
Song, QJ ;
Ai, HX ;
Chu, J ;
Li, W .
BEHAVIOURAL BRAIN RESEARCH, 2005, 157 (02) :245-251
[42]  
Zakharova NS, 1998, APPL BIOCHEM MICRO+, V34, P182
[43]   D-Galactose injured neurogenesis in the hippocampus of adult mice [J].
Zhang, Q ;
Li, XK ;
Cui, X ;
Zuo, PP .
NEUROLOGICAL RESEARCH, 2005, 27 (05) :552-556
[44]   Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose [J].
Zhang, Xiu Li ;
Jiang, Bo ;
Li, Zhi Bo ;
Hao, Shuang ;
An, Li Jia .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2007, 88 (01) :64-72
[45]  
[张秀娟 Zhang Xiujuan], 2002, [中国微生态学杂志, Chinese Journal of Microecology], V14, P277
[46]   Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa [J].
Zhang, Xluli ;
Zhang, Aihong ;
Jiang, Bo ;
Bao, Yongming ;
Wang, Jingyun ;
An, Lijia .
PHYTOMEDICINE, 2008, 15 (6-7) :484-490
[47]   Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by D-galactose in ICR mice [J].
Zhong, Shu-Zhi ;
Ge, Qing-Hua ;
Qu, Rong ;
Li, Qiao ;
Ma, Shi-Ping .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2009, 277 (1-2) :58-64