Synthesis of 4-[18F]fluorophenylalkenes and -arenes via palladium-catalyzed coupling of 4-[18F]fluoroiodobenzene with vinyl and aryl tin reagents

被引：25
作者：
Allain-Barbier, L
Lasne, MC
Perrio-Huard, C
Moreau, B
Barre, L
机构：
[1] Inst Sci Mat & Rayonnement, CNRS, UMR 6507, F-14050 Caen, France
[2] Univ Caen Basse Normandie, F-14074 Caen, France
[3] CEA, Ctr Cyceron, GDRM, F-14074 Caen, France
来源：
ACTA CHEMICA SCANDINAVICA | 1998年 / 52卷 / 04期
关键词：
D O I：
10.3891/acta.chem.scand.52-0480
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cross-coupling reaction of 4-[F-18]fluoroiodobenzene 3a with vinyl or aryl tin reagents in the presence of tetrakis(triphenylphosphine)palladium was found to provide a convenient and rapid method for the preparation of 4-[F-18]fluorostyrene or 4-[F-18]fluorobiphenyl within 45-50 min and 47% or 86% radiochemical yields, respectively, counted from 3a. (E)-N-{3-(4-[F-18]fluorophenyl}prop-2-enyl]piperidine 2a was obtained within 45 min and in 80% radiochemical yield from 3a. 4-[F-18]Fluorobromobenzene 4a was prepared in 24-48% yield from 2-nitro-5-bromobenzaldehyde and [F-18]KF in 95 min.
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页码：480 / 489
页数：10
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