The activated core approach to combinatorial chemistry: A selection of new core molecules

被引：91
作者：
Pryor, KE
Shipps, GW
Skyler, DA
Rebek, J [1 ]
机构：
[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[3] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
TETRAHEDRON | 1998年 / 54卷 / 16期
关键词：
D O I：
10.1016/S0040-4020(98)00139-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four new activated core molecules suitable for use in solution-phase combinatorial organic chemistry have been prepared. These molecules represent an attempt to further explore shape-space and increase the structural diversity of prepared libraries, as well as to incorporate recognition elements in the cores to increase the chances for interaction with biological targets. Demonstrations of deconvolution strategies used to simplify complex libraries and build individual molecular species based on the cores are also provided. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.
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收藏
页码：4107 / 4124
页数：18
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