A pH-responsive photoacoustic imaging probe for tumor pH imaging in vivo based on polyaniline-bovine serum albumin

被引：10
作者：
Yang, Ziyi [1 ,2 ,3 ,4 ]
Gu, Bingxin [1 ,2 ,3 ,4 ]
Jiang, Chunjuan [1 ,2 ,3 ,4 ]
Zhang, Le [1 ,2 ,3 ,4 ]
Liu, Qiufang [1 ,2 ,3 ,4 ]
Song, Shaoli [1 ,2 ,3 ,4 ]
机构：
[1] Fudan Univ, Dept Nucl Med, Shanghai Canc Ctr, Shanghai 200032, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
[3] Fudan Univ, Ctr Biomed Imaging, Shanghai, Peoples R China
[4] Shanghai Engn Res Ctr Mol Imaging Probes, Shanghai, Peoples R China
来源：
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2021年 / 33卷
基金：
中国国家自然科学基金;
关键词：
Photoacoustic imaging detection; pH-responsive; Polyaniline probe; Tumor pH; pH detection; INTRACELLULAR PH; NANOPARTICLE;
D O I：
10.1016/j.nano.2020.102356
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Precise pH detection in tumors can guide the design of pH-responsive drugs and theranostic agents to improve treatment efficacy. However, most reported pH-responsive probes are fluorescent probes, for which in vivo application is limited by low probe penetration depth. In this study, a pH-responsive polyaniline-bovine serum albumin (BSA) probe was constructed for precise pH detection in tumors using photoacoustic imaging. The probe can be used to generate high-resolution images of deep biological tissues. The photoacoustic signal of the polyaniline BSA probe exhibits a clear linear relationship with pH in the range of 5 6.8 both in vitro and in vivo, indicating that the probe is ideal for precise pH detection in most tumors. The polyaniline-BSA probe also exhibits satisfactory biocompatibility, low toxicity, fast response, and good reversibility. This work provides a useful in vivo pH detection probe for developing pH-responsive drugs and theranostic agents. (C) 2021 Elsevier Inc. All rights reserved.
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页数：9
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