Cytotoxic activity of natural labdanes and their semi-synthetic modified derivatives from Croton oblongifolius

被引：19
作者：
Sommit, D
Petsom, A
Ishikawa, T
Roengsumran, S
机构：
[1] Chulalongkorn Univ, Dept Chem, Fac Sci, Bangkok 10330, Thailand
[2] Chiba Univ, Fac Pharmaceut Sci, Inage Ku, Chiba 260, Japan
来源：
PLANTA MEDICA | 2003年 / 69卷 / 02期
关键词：
D O I：
10.1055/s-2003-37708
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Labda-7,12(E),14-triene-17-oic acid, previously isolated from Croton oblongifolius, and its derivatives were investigated for cytotoxicity against five human tumor cell lines. Six of these compounds, labda-7,12(E),14-triene-17-al, 17-hydroxylabda-7,12(E),14-triene, 17-acetoxylabda-7,12(E),14-triene, 15-hydroxylabda-7,13(E)-diene-17,12-olide, labda-7,13(E)-diene-17,12-olide, and 12,17-dihydroxylabda-7,13(E)-diene showed nonspecific, moderate, cytotoxicity against all cell lines, whereas the other compounds were inactive.
引用
收藏
页码：167 / 170
页数：4
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