Sleep and Human Aging

被引：769

作者：

Mander, Bryce A. ^{[1
]}

Winer, Joseph R. ^{[1
]}

Walker, Matthew P. ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Dept Psychol, Sleep & Neuroimaging Lab, 3210 Tolman Hall, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

来源：

NEURON | 2017年 / 94卷 / 01期

关键词：

SLOW-WAVE SLEEP; AGE-RELATED-CHANGES; DECLARATIVE MEMORY CONSOLIDATION; HIPPOCAMPAL-DEPENDENT MEMORY; MILD COGNITIVE IMPAIRMENT; CURRENT STIMULATION TDCS; SELF-REPORTED SLEEP; OLDER-ADULTS; LOCUS-COERULEUS; OSCILLATORY ACTIVITY;

D O I：

10.1016/j.neuron.2017.02.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Older adults do not sleep as well as younger adults. Why? What alterations in sleep quantity and quality occur as we age, and are there functional consequences? What are the underlying neural mechanisms that explain age-related sleep disruption? This review tackles these questions. First, we describe canonical changes in human sleep quantity and quality in cognitively normal older adults. Second, we explore the underlying neurobiological mechanisms that may account for these human sleep alterations. Third, we consider the functional consequences of age-related sleep disruption, focusing on memory impairment as an exemplar. We conclude with a discussion of a still-debated question: do older adults simply need less sleep, or rather, are they unable to generate the sleep that they still need?

引用

页码：19 / 36

页数：18

共 157 条

[31] The effect of donepezil on sleep and REM sleep EEG in patients with Alzheimer disease: A double-blind placebo-controlled study [J].