Eating at the Table of Another: Metabolomics of Host-Parasite Interactions

被引：66

作者：

Kafsack, Bjorn F. C. ^{[1
]}

Llinas, Manuel ^{[1
,2
]}

机构：

[1] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA

[2] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

CELL HOST & MICROBE | 2010年 / 7卷 / 02期

关键词：

NUCLEAR-MAGNETIC-RESONANCE; HUMAN MALARIA PARASITE; PROCYCLIC TRYPANOSOMA-BRUCEI; PATHOGEN TOXOPLASMA-GONDII; PLASMODIUM-FALCIPARUM; MASS-SPECTROMETRY; CHLOROQUINE RESISTANCE; COMPUTATIONAL ANALYSIS; ENTAMOEBA-HISTOLYTICA; PROTEIN INTERACTIONS;

D O I：

10.1016/j.chom.2010.01.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The application of metabolomics, the global analysis of metabolite levels, to the study of protozoan parasites has become an important tool for understanding the host-parasite relationship and holds promise for the development of direly needed therapeutics and improved diagnostics. Research advances over the past decade have opened the door for a systems biology approach to protozoan parasites with metabolomics, providing a crucial readout of metabolic activity. In this review, we highlight recent metabolomic approaches to protozoan parasites, including metabolite profiling, integration with genomics, transcription, and proteomic analysis, and the use of metabolic fingerprints for the diagnosis of parasitic infections.

引用

页码：90 / 99

页数：10

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