Effects of Hemostatic Agents on Fibroblast Cells

被引：9

作者：

Emes, Yusuf ^{[1
]}

Aybar, Buket ^{[1
]}

Vural, Pervin ^{[2
]}

Issever, Halim ^{[3
]}

Yalcin, Serhat ^{[1
]}

Atalay, Belir ^{[1
]}

Dincol, Emir ^{[4
]}

Bilir, Ayhan ^{[5
]}

机构：

[1] Istanbul Univ, Dept Oral & Maxillofacial Surg, Fac Dent, TR-34104 Istanbul, Turkey

[2] Istanbul Univ, Dept Biochem, Istanbul Fac Med, TR-34104 Istanbul, Turkey

[3] Istanbul Univ, Istanbul Fac Med, Dept Publ Hlth, TR-34104 Istanbul, Turkey

[4] Istanbul Univ, Fac Dent, Dept Endodont, TR-34104 Istanbul, Turkey

[5] Istanbul Univ, Istanbul Fac Med, Dept Histol & Embryol, TR-34104 Istanbul, Turkey

来源：

IMPLANT DENTISTRY | 2014年 / 23卷 / 06期

关键词：

ankaferd; fibroblast; cell culture; SEM; ANKAFERD BLOOD STOPPER(R); IN-VITRO; GROWTH-FACTOR; EPIDERMAL REGENERATION; DIFFERENTIATION; PROLIFERATION; EXPRESSION; KERATINOCYTES; CYTOTOXICITY; PROMOTE;

D O I：

10.1097/ID.0000000000000159

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Purpose: Hemostatic agents may be used topically to control hemorrhage, especially in patients with bleeding disorders. The agent used may have a negative effect on the tissue prolonging the healing time. The aim of this study was to compare the effects of 3 different hemostatic agents on fibroblast cells on a rat primary fibroblast cell culture model. Materials and Methods: Ankaferd Blood Stopper (ABD) (Ankaferd Pharmaceuticals Cosmetics Production and Marketing Co.), fibrin glue, and tranexamic acid were the agents to be evaluated for their effects on cell proliferation, cell numbers, cell viability, and cell morphology. Also lactate dehydrogenase, basic fibroblast growth factor, and vascular endothelial growth factor C levels were measured. Results: It was found that all of the agents used in the study have negative effects on fibroblasts, with ABD having the lowest values of cell proliferation, cell number, and cell viability. Conclusion: The results of this study indicate that ABD, fibrin glue, and tranexamic acid may negatively affect tissue healing.

引用

页码：641 / 647

页数：7

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