A Facile and Mild Synthesis of Enamides using a Gold-Catalyzed Nucleophilic Addition to Allenamides

被引：78
|
作者：
Kimber, Marc C. [1 ]
机构：
[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 05期
关键词：
STEREOSELECTIVE-SYNTHESIS; OXYALLYL CATIONS; CYCLOADDITION REACTIONS; ISOMERIZATION; AMIDATION; SALICYLIHALAMIDE; HYDROGENATION; CYCLIZATIONS; ALKENES; REGIO;
D O I：
10.1021/ol1001494
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild and facile synthesis of enamides has been developed, based on nucleophilic addition of electron-rich aromatic and heteroaromatics to an allenamide unit catalyzed by a gold salt. Yields for the transformation were 29-98%.
引用
收藏
页码：1128 / 1131
页数：4
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