Evidence of an Association Between Vitamin D Deficiency and Preterm Birth and Preeclampsia: A Critical Review

被引:32
作者
Woo, Jennifer [1 ,2 ]
Giurgescu, Carmen [3 ]
Wagner, Carol L. [4 ]
机构
[1] Texas Womans Univ, Denton, TX 76204 USA
[2] Parkland Mem Hosp & Affiliated Inst, Dallas, TX 75235 USA
[3] Ohio State Univ, Coll Nursing, Columbus, OH 43210 USA
[4] Med Univ South Carolina, Charleston, SC 29425 USA
关键词
25(OH)D; vitamin D; vitamin D deficiency; preeclampsia; preterm birth; D SUPPLEMENTATION; PREGNANCY; HEALTH; OUTCOMES; RISK; INSUFFICIENCY; METAANALYSIS; PREVENTION; IMPACT; TRIAL;
D O I
10.1111/jmwh.13014
中图分类号
R47 [护理学];
学科分类号
1011 ;
摘要
Vitamin D deficiency has been associated with adverse pregnancy and birth outcomes such as increased risk for preterm birth and preeclampsia. This state of the science review analyzed recently published meta-analyses and relevant studies that have evaluated the association between vitamin D deficiency and preeclampsia or preterm birth. The results suggest that a positive association between vitamin D deficiency and preterm birth exists. However, the findings of the relationship between vitamin D deficiency and preeclampsia were inconclusive, possibly because of the need for supplementation to occur prior to placentation. This may be because of a lack of studies with ethnic minority populations, who are more likely to experience vitamin D deficiency, and inadequate supplementation doses used for treatment of vitamin D deficiency. Health care providers should screen pregnant women at risk for vitamin D deficiency and supplement women accordingly based on their vitamin D status. Lastly, well-designed and standardized clinical trials need to include large cohorts of minority pregnant women to establish the impact of vitamin D supplementation on improving preterm birth and preeclampsia risk in pregnancy.
引用
收藏
页码:613 / 629
页数:17
相关论文
共 71 条
[1]   Vitamin D status in early pregnancy and risk of preeclampsia [J].
Achkar, Madonna ;
Dodds, Linda ;
Giguere, Yves ;
Forest, Jean-Claude ;
Armson, B. Anthony ;
Woolcott, Christy ;
Agellon, Sherry ;
Spencer, Anne ;
Weiler, Hope A. .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2015, 212 (04) :511.e1-511.e7
[2]   Effect of vitamin D3 supplementation in pregnancy on risk of pre-eclampsia - Randomized controlled trial [J].
Ali, Aisha Mansoor ;
Alobaid, Abdulaziz ;
Malhis, Tasnim Nidal ;
Khattab, Ahmad Fawzi .
CLINICAL NUTRITION, 2019, 38 (02) :557-563
[3]   Maternal vitamin D insufficiency and risk of adverse pregnancy and birth outcomes: A systematic review and meta-analysis of longitudinal studies [J].
Amegah, A. Kofi ;
Klevor, Moses K. ;
Wagner, Carol L. .
PLOS ONE, 2017, 12 (03)
[4]  
[Anonymous], GUID VIT D SUPPL PRE
[5]  
[Anonymous], 2019, J MIDWIFERY WOM HEAL, V64, P361
[6]  
[Anonymous], 2011, OBSTET GYNECOL
[7]   Vitamin D and Inflammatory Cytokines in Healthy and Preeclamptic Pregnancies [J].
Barrera, David ;
Diaz, Lorenza ;
Noyola-Martinez, Nancy ;
Halhali, Ali .
NUTRIENTS, 2015, 7 (08) :6465-6490
[8]   Vitamin D Metabolism, Mechanism of Action, and Clinical Applications [J].
Bikle, Daniel D. .
CHEMISTRY & BIOLOGY, 2014, 21 (03) :319-329
[9]   Vitamin D May Be a Link to Black-White Disparities in Adverse Birth Outcomes [J].
Bodnar, Lisa M. ;
Simhan, Hyagriv N. .
OBSTETRICAL & GYNECOLOGICAL SURVEY, 2010, 65 (04) :273-284
[10]   Racial/ethnic disparities in obstetric outcomes and care: prevalence and determinants [J].
Bryant, Allison S. ;
Worjoloh, Ayaba ;
Caughey, Aaron B. ;
Washington, A. Eugene .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2010, 202 (04) :335-343