Insights into the diagnosis of hepatocellular carcinomas with hepatobiliary MRI

被引:39
作者
Vilgrain, Valerie [1 ,2 ]
Van Beers, Bernard E. [1 ,2 ,3 ]
Pastor, Catherine M. [2 ,4 ]
机构
[1] Univ Hosp Paris Nord Val de Seine, Dept Radiol, 100 Blvd Gen Leclerc, F-92118 Clichy, France
[2] Univ Paris Diderot, Sorbonne Paris Cite, Paris, France
[3] Ctr Rech Inflammat, INSERM, U1149, Paris, France
[4] Hop Univ Geneve, Dept Imagerie & Sci Informat Med, Rue Gabrielle Perret Gentil 4, CH-1205 Geneva, Switzerland
关键词
Hepatocellular carcinoma; Hepatobiliary MRI; Hepatocyte transporters; DIETHYLENETRIAMINE-PENTAACETIC ACID; HEPATOCYTE NUCLEAR FACTOR-1-ALPHA; ANION-TRANSPORTING POLYPEPTIDES; GADOXETIC ACID; HEPATIC-UPTAKE; CANALICULAR TRANSPORTERS; IMAGING-CORRELATION; SIGNAL-INTENSITY; BILE FORMATION; MESSENGER-RNA;
D O I
10.1016/j.jhep.2015.11.016
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The incidence of hepatocellular carcinomas (HCCs) has increased worldwide in line with an improved screening by high-resolution imaging of cirrhotic livers. Besides abdominal ultrasonography and computerised tomography, magnetic resonance imaging (MRI) is an important tool to detect HCCs. With commercialisation of MR hepatobiliary contrast agents that cross membrane transporters in hepatocytes or tumour cells, MRI adds new information to detect and characterise HCCs. When tumour cells lose organic anion transporting polypeptides (OATP1B1/B3) in cell membranes facing sinusoidal blood, tumours appear hypointense (decreased contrast agent concentrations) in comparison to surrounding normal or cirrhotic liver that retains OATP1B1/B3 expression. However, expression, regulation, and prognostic significance of transporter evolution along carcinogenesis are not completely known. Moreover, understanding signal intensities in focal lesions also relies on transport functions of cellular efflux transporters. This manuscript reviews all the publications that associate liver imaging with hepatobiliary contrast agents and expression of transporters. The regulation of transporters along carcinogenesis to anticipate the prognosis of focal lesions is also included. (C) 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:708 / 716
页数:9
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