Breaking the vicious cycle between breast cancer cells and tumor-associated macrophages

被引：24
|
作者：
Su, Shicheng [1 ,2 ,3 ]
Wu, Wei [1 ,2 ,3 ]
He, Chonghua [1 ,2 ,3 ]
Liu, Qiang [1 ,2 ,3 ]
Song, Erwei [1 ,2 ,3 ]
机构：
[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Med Res Ctr, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou 510275, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Breast Tumor Ctr, Guangzhou 510275, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Oncol, Guangzhou 510275, Guangdong, Peoples R China
来源：
ONCOIMMUNOLOGY | 2014年 / 3卷 / 08期
关键词：
EMT; humanized mice; tumor-associated macrophages; tumor metabolism; METASTASIS; VACCINE;
D O I：
10.4161/21624011.2014.953418
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We recently identified a vicious cycle between granulocyte macrophage colony stimulating factor (GM-CSF) arising from breast cancer cells that have undergone epithelial-mesenchymal transition (EMT) and the tumor-associated macrophage (TAM)-derived chemokine CCL18, a signaling loop that promotes tumor metastasis. Tumor-derived lactate skews GM-CSF-activated macrophages to an anti-inflammatory and immunosuppressive M2 phenotype, suggesting that breaking this cycle in combination with glycolysis inhibitors may inhibit tumor development.
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页数：3
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