Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?

被引：16

作者：

Belen Galvan, Ana ^{[1
,2
]}

Mallo, Mar ^{[1
,2
]}

Arenillas, Leonor ^{[1
]}

Salido, Marta ^{[1
]}

Espinet, Blanca ^{[1
]}

Pedro, Carmen ^{[3
]}

Florensa, Lourdes

Serrano, Sergi ^{[4
]}

Sole, Francesc ^{[1
,2
]}

机构：

[1] Hosp del Mar, Serv Patol, Lab Citogenet Mol, GRETNHE,IMIM, Barcelona 08003, Spain

[2] Univ Autonoma Barcelona, Dept Biol Cel lular Fisiol & Immunol, Bellaterra, Spain

[3] IMIM Hosp Mar, GRETNHE, Serv Hematol Clin, Barcelona, Spain

[4] IMIM Hosp Mar, GRETNHE, Serv Patol, Barcelona, Spain

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 09期

关键词：

Myelodysplastic syndrome; Acute myeloid leukemia; Karyotype; FISH; Monosomy; 5; 5q deletion; MDS; CYTOGENETICS; ABNORMALITIES; PROGNOSIS; KARYOTYPE;

D O I：

10.1016/j.leukres.2010.03.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1242 / 1245

页数：4

共 13 条

[1] Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia:: results from Cancer and Leukemia Group B (CALGB 8461) [J].

Byrd, JC ;

Mrózek, K ;

Dodge, RK ;

Carroll, AJ ;

Edwards, CG ;

Arthur, DC ;

Pettenati, MJ ;

Patil, SR ;

Rao, KW ;

Watson, MS ;

Koduru, PRK ;

Moore, JO ;

Stone, RM ;

Mayer, RJ ;

Feldman, EJ ;

Davey, FR ;

Schiffer, CA ;

Larson, RA ;

Bloomfield, CD .

BLOOD, 2002, 100 (13) :4325-4336

[2] Implementation of standardized international karyotype scoring practices is needed to provide uniform and systematic evaluation for patients with myelodysplastic syndrome using IPSS criteria: An International Working Group on MDS Cytogenetics Study [J].

Chun, Kathy ;

Hagemeijer, Anne ;

Iqbal, Anwar ;

Slovak, Marilyn L. .

LEUKEMIA RESEARCH, 2010, 34 (02) :160-165

[3] Single nucleotide polymorphism arrays complement metaphase cytogenetics in detection of new chromosomal lesions in MDS [J].

Gondek, L. P. ;

Tiu, R. ;

Haddad, A. S. ;

O'Keefe, C. L. ;

Sekeres, M. A. ;

Theil, K. S. ;

Maciejewski, J. P. .

LEUKEMIA, 2007, 21 (09) :2058-2061

[4] International scoring system for evaluating prognosis in myelodysplastic syndromes [J].

Greenberg, P ;

Cox, C ;

LeBeau, MM ;

Fenaux, P ;

Morel, P ;

Sanz, G ;

Sanz, M ;

Vallespi, T ;

Hamblin, T ;

Oscier, D ;

Ohyashiki, K ;

Toyama, K ;

Aul, C ;

Mufti, G ;

Bennett, J .

BLOOD, 1997, 89 (06) :2079-2088

[5] The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial [J].

Grimwade, D ;

Walker, H ;

Harrison, G ;

Oliver, F ;

Chatters, S ;

Harrison, CJ ;

Wheatley, K ;

Burnett, AK ;

Goldstone, AH .

BLOOD, 2001, 98 (05) :1312-1320

[6] Updated cytogenetic risk features in MDS - present state [J].

Haase, D. ;

Schanz, J. ;

Tuechler, H. ;

Sole, F. ;

Mallo, M. ;

Hildebrandt, B. ;

Slovak, M. L. ;

Ohyashiki, K. ;

Steidl, C. ;

Fonatsch, C. ;

Pfeilstoecker, M. ;

Noesslinger, T. ;

Valent, P. ;

Giagounidis, A. ;

Luebbert, M. ;

Stauder, R. ;

Krieger, O. ;

LeBeau, M. ;

Bennett, J. ;

Greenberg, P. ;

Germing, U. .

LEUKEMIA RESEARCH, 2009, 33 :S9-S10

[7] New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes:: evidence from a core dataset of 2124 patients [J].

Haase, Detlef ;

Germing, Ulrich ;

Schanz, Julie ;

Pfeilstoecker, Michael ;

Noesslinger, Thomas ;

Hildebrandt, Barbara ;

Kundgen, Andrea ;

Luebbert, Michael ;

Kunzmann, Regina ;

Giagounidis, Aristoteles A. N. ;

Aul, Carlo ;

Truemper, Lorenz ;

Krieger, Otto ;

Stauder, Reinhard ;

Mueller, Thomas H. ;

Wimazal, Friedrich ;

Valent, Peter ;

Fonatsch, Christa ;

Steidl, Christian .

BLOOD, 2007, 110 (13) :4385-4395

[8] Redefining monosomy 5 by molecular cytogenetics in 23 patients with MDS/AML [J].

Herry, Angele ;

Douet-Guilbert, Nathalie ;

Morel, Frederic ;

Le Bris, Marie-Jose ;

De Braekeleer, Marc .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2007, 78 (06) :457-467

[9] The Heterogeneous Prognosis of Patients With Myelodysplastic Syndrome and Chromosome 5 Abnormalities How Does It Relate to the Original Lenalidomide Experience in MDS? [J].

Kantarjian, Hagop ;

O'Brien, Susan ;

Ravandi, Farhad ;

Borthakur, Gautam ;

Faderl, Stefan ;

Bueso-Ramos, Carlos ;

Abruzzo, Lynne ;

Pierce, Sherry ;

Shan, Jianqin ;

Issa, Jean-Pierre ;

Garcia-Manero, Guillermo .

CANCER, 2009, 115 (22) :5202-5209

[10] FISH and SNP-A karyotyping in myelodysplastic syndromes: Improving cytogenetic detection of del(5q), monosomy 7, del(7q), trisomy 8 and del(20q) [J].

Makishima, Hideki ;

Rataul, Manjot ;

Gondek, Lukasz P. ;

Huh, Jungwon ;

Cook, James R. ;

Theil, Karl S. ;

Sekeres, Mikkael A. ;

Kuczkowski, Elizabeth ;

O'Keefe, Christine ;

Maciejewski, Jaroslaw P. .

LEUKEMIA RESEARCH, 2010, 34 (04) :447-453

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