Contemplating the role of genetic variants of HHEX, CDKAL1, WFS1 and SLC30A8 genes of TYPE-2 diabetes in Asians ethnic groups

被引：12

作者：

Goyal, Yamini ^{[1
]}

Verma, Amit Kumar ^{[1
,2
]}

Joshi, P. C. ^{[2
]}

Dev, Kapil ^{[1
]}

机构：

[1] Jamia Millia Islamia, Dept Biotechnol, New Delhi, India

[2] Gurukula Kangri Univ, Dept Zool & Env Sci, Haridwar, India

来源：

GENE REPORTS | 2019年 / 17卷

关键词：

GWAS; Pancreatic beta-cells; Type; 2; diabetes; GENOME-WIDE ASSOCIATION; ENDOPLASMIC-RETICULUM STRESS; BETA-CELL FUNCTION; COMMON VARIANTS; RISK LOCI; INSULIN-SECRETION; ZINC TRANSPORTER; OPTIC ATROPHY; MELLITUS; CDKN2A/B;

D O I：

10.1016/j.genrep.2019.100465

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Type 2 diabetes (T2D) is a chronic disorder and caused by both environmental and genetic factors. GWAS have identified > 150 SNPs associated with T2D. In this review, susceptibility of different variants of T2D genes (HHEX, CDKAL1, WFS1 and SLC30A8) in different Asian populations is discussed. These genes play role in pancreatic beta-cell functioning, survival, insulin sensitivity and secretion. Ethnic difference in Asian and European populations leads to change in impact of gene on different populations. Hence, Asians are highly susceptible to variants of these type 2 diabetes genes than Europeans. We discuss the linkage of variants of these genes with type 2 diabetes risk among various subgroups of Asian population and compare the Asian groups with European groups.

引用

页数：6

共 68 条

[1] Increased DNA methylation of the SLC30A8 gene promoter is associated with type 2 diabetes in a Malay population [J].

Abu Seman, Norhashimah ;

Mohamud, Wan Nazaimoon Wan ;

Ostenson, Claes-Goran ;

Brismar, Kerstin ;

Gu, Harvest F. .

CLINICAL EPIGENETICS, 2015, 7 :7-30

[2] An update on the etiology and epidemiology of diabetes mellitus [J].

Adeghate, Ernest ;

Schattner, Peter ;

Dunn, Earl .

DIABETES MELLITUS AND ITS COMPLICATIONS: MOLECULAR MECHANISMS, EPIDEMIOLOGY, AND CLINICAL MEDICINE, 2006, 1084 :1-29

[3] Genetics of type 2 diabetes [J].

Ali, Omar .

WORLD JOURNAL OF DIABETES, 2013, 4 (04) :114-123

[4] Replication of Type 2 Diabetes Candidate Genes Variations in Three Geographically Unrelated Indian Population Groups [J].

Ali, Shafat ;

Chopra, Rupali ;

Manvati, Siddharth ;

Singh, Yoginder Pal ;

Kaul, Nabodita ;

Behura, Anita ;

Mahajan, Ankit ;

Sehajpal, Prabodh ;

Gupta, Subash ;

Dhar, Manoj K. ;

Chainy, Gagan B. N. ;

Bhanwer, Amarjit S. ;

Sharma, Swarkar ;

Bamezai, Rameshwar N. K. .

PLOS ONE, 2013, 8 (03)

[5] Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas [J].

Bort, R ;

Martinez-Barbera, JP ;

Beddington, RSP ;

Zaret, KS .

DEVELOPMENT, 2004, 131 (04) :797-806

[6] Identification and cloning of a β-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules [J].

Chimienti, F ;

Devergnas, S ;

Favier, A ;

Seve, M .

DIABETES, 2004, 53 (09) :2330-2337

[7] ZnT-8, a pancreatic beta-cell-specific zinc transporter [J].

Chimienti, F ;

Favier, A ;

Seve, M .

BIOMETALS, 2005, 18 (04) :313-317

[8] In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion [J].

Chimienti, Fabrice ;

Devergnas, Severine ;

Pattou, Francois ;

Schuit, Frans ;

Garcia-Cuenca, Rachel ;

Vandewalle, Brigitte ;

Kerr-Conte, Julie ;

Van Lommel, Leentje ;

Grunwald, Didier ;

Favier, Alain ;

Seve, Michel .

JOURNAL OF CELL SCIENCE, 2006, 119 (20) :4199-4206

[9] The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel [J].

Chistiakov, Dimitry A. ;

Potapov, V. A. ;

Smetanina, S. A. ;

Bel'chikova, L. N. ;

Suplotova, L. A. ;

Nosikov, V. V. .

ACTA DIABETOLOGICA, 2011, 48 (03) :227-235

[10]

Chistiakov Dimitry A, 2010, Rev Diabet Stud, V7, P285, DOI 10.1900/RDS.2010.7.285

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