Synthesis and cytotoxic activity of fluorinated analogues of Goniothalamus lactones. Impact of fluorine on oxidative processes

被引：20

作者：

Dumitrescu, Lidia ^{[1
]}

Doan Thi Mai Huong ^{[2
]}

Nguyen Van Hung ^{[2
]}

Crousse, Benoit ^{[1
]}

Bonnet-Delpon, Daniele ^{[1
]}

机构：

[1] Univ Paris 11, Fac Pharm, CNRS, UMR 8076,IFR 141, F-92290 Chatenay Malabry, France

[2] Vietnam Acad Sci & Technol, Inst Chem, Lab Terpenoid Chem, Hanoi, Vietnam

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 07期

关键词：

Styryl-lactones; Metabolism; Fluorine; Antitumor; (+)-GONIOTHALAMIN; (R)-GONIOTHALAMIN; DERIVATIVES; EFFICIENT; OXIDE; ACID;

D O I：

10.1016/j.ejmech.2010.03.032

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel fluorinated analogues of goniothalamin 1 and howiinol A 2 have been prepared from trifluorocrotonate derivatives. Trifluoromethyl goniothalamin (R/S) 4 showed a slightly lower activity than 1, while the trifluoromethyl howiinol A 16 exhibited similar activities on several cell lines in the micromolar range. Unlike (R) goniothalamin and howiinol A, trifluoromethyl parent compounds remained unchanged when submitted to biomimetic oxidative systems. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：3213 / 3218

页数：6

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