Nickel-catalyzed Suzuki-Miyaura cross-coupling of C-F bonds

被引：17

作者：

Zhang, Tianhao ^{[1
]}

Nohira, Itsuki ^{[1
]}

Chatani, Naoto ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chemisuy, Suita, Osaka 5650871, Japan

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 14期

关键词：

METHYL ETHERS; PALLADIUM; ARYL; ACTIVATION; ESTERS;

D O I：

10.1039/d1qo00656h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient Suzuki-Miyaura cross-coupling of ortho-fluoro aromatic secondary amides with aryl boronates is described. The use of (KOBu)-Bu-t is essential for the reaction to proceed. The function of the base is to abstract a proton from an amide nitrogen to generate a weak conjugate base, such as an amidate, which functions as a directing group. The reaction proceeds effectively, even at 60 degrees C. The reaction exhibits a good tolerance for functional groups and a broad scope for aromatic amides.

引用

页码：3783 / 3787

页数：5

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